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Functional bowel disorders and functional abdominal pain
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. Expand
Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain.
The fixed-ratio combination of oxycodone PR/naloxone PR is superior to oxy codone PR alone, offering patients effective analgesia while significantly improving opioid-induced constipation. Expand
Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation
The Bowel Function Index is a valid and reliable instrument for the assessment of opioid-induced constipation in chronic pain patients and psychometric analyses from clinical trials support the BFI's psychometric properties. Expand
Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders
The nonselective 5‐HT4 receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs) and the use of these drugs in clinical practice is still under investigation. Expand
Symptoms in gastro-oesophageal reflux disease
Of several symptoms thought to be related to gastrooesophageal reflux disease (GORD), only heartburn and acid regurgitation occurred in more of the patients with GORD (as determined by pH monitoring) than of those with normal pH monitoring. Expand
Tegaserod, a 5‐HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
To investigate the efficacy and safety of tegaserod, a novel 5‐HT4 receptor partial agonist, in a randomized, double‐blind, placebo‐controlled, 12‐week treatment, multicentre study.
Myths and Misconceptions About Chronic Constipation
There is no evidence that constipation can successfully be treated by increasing fluid intake unless there is evidence of dehydration, and in the elderly constipation may correlate with decreased physical activity, but many cofactors are likely to play a role. Expand
Esophageal 24-h pH monitoring: is prior manometry necessary for correct positioning of the electrode?
It is concluded that the esophagogastric junction can usually be identified with sufficient accuracy by the measurement of the pH-step between stomach and esophagus, and fluoroscopy is far less accurate than pH- step, and should not be used. Expand
Optimal thresholds, sensitivity, and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease.
It is concluded that rather simple criteria yield a high diagnostic accuracy in the evaluation of long-term esophageal pH-metry, and a prospective and independent confirmation of these criteria is needed. Expand
Symptoms in chronic constipation
Symptoms of chronically constipated patients are not well suited to differentiate between the pathophysiologic subgroups suffering chronic constipation; the symptom “necessity to strain” is much better suited. Expand