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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have beenExpand
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Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
BACKGROUND The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified byExpand
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Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study.
RATIONALE Muscle wasting in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis and is not readily assessed by measures of body mass index (BMI). BMI does notExpand
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent wereExpand
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Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease
Background: Eosinophilic airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting potential sharedExpand
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Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans.
BACKGROUND COPD patients have a great burden of comorbidity. However, it is not well established whether this is due to shared risk factors such as smoking, if they impact patients exercise capacityExpand
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Pulmonary Function Reduction in Diabetes With and Without Chronic Obstructive Pulmonary Disease
OBJECTIVE Diabetes damages major organ systems through disrupted glycemic control and increased inflammation. The effects of diabetes on the lung have been of interest for decades, but the modestExpand
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A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
BackgroundPulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflowExpand
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Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk.
RATIONALE Former smoking history and chronic obstructive pulmonary disease (COPD) are potential risk factors for osteoporosis and fractures. Under existing guidelines for osteoporosis screening,Expand
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Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease.
BACKGROUND Bronchial airway expression profiling has identified inflammatory subphenotypes of asthma, but the invasiveness of this technique has limited its application to childhood asthma. Expand
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