S. Lukehart

Publications221
h-index58
Citations10,948
Highly Influential Citations377
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • J. Radolf
  • 265 Publications • 21,582 Citations
  • D. Šmajs
  • 248 Publications • 3,723 Citations
  • L. Giacani
  • 80 Publications • 1,367 Citations
  • C. Godornes
  • 42 Publications • 2,164 Citations
  • Publications
  • Influence
Biological Basis for Syphilis
SUMMARY Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp. pallidum. Clinical manifestations separate the disease into stages; late stages of disease are now…
View on Publisher
Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis.
TLDR
An enhanced T. pallidum strain typing system that shows biological and clinical relevance is described and is believed to be the most discriminating typing system.
View on PubMed
Macrolide resistance in Treponema pallidum in the United States and Ireland.
TLDR
An HIV-infected patient in San Francisco with primary syphilis was treated with azithromycin, but the lesion did not resolve, and a mutation in the 23S rRNA genes of T. pallidum was identified.
View on PubMed
Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features.
TLDR
Serum RPR titer helps predict the likelihood of neurosyphilis and HIV-induced immune impairment may increase the risk of neuroSyphilis.
View on PubMed
Syphilis: using modern approaches to understand an old disease.
  • E. Ho, S. Lukehart
  • Biology, Medicine
    The Journal of clinical investigation
  • 1 December 2011
TLDR
Recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks are reviewed.
View on PubMed
Quantitation of rabbit cytokine mRNA by real-time RT-PCR.
View on PubMed
Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response
TLDR
Antibodies directed to purified recombinant variable domain of Tpr K can opsonize T. pallidum, Nichols strain, for phagocytosis, supporting the hypothesis that this portion of the protein is exposed at the surface of the treponeme.
View PDF
Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens
TLDR
It is reviewed how bacterial, protozoan and fungal pathogens from distant evolutionary lineages have evolved surprisingly similar mechanisms of antigenic variation to avoid eradication by the host immune system and can therefore maintain persistent infections and ensure their transmission to new hosts.
View on Nature
Genital ulceration as a risk factor for human immunodeficiency virus infection.
TLDR
Aggressive control of chancroid and syphilis may offer one very feasible approach to reducing transmission of HIV in this region.
View on PubMed
Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92.
TLDR
It is demonstrated that Tp92 is an invariant, immunoprotective antigen that may be present on the surface of T. pallidum and may represent a potential vaccine candidate for syphilis.
View on PubMed
...
...