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Biological Basis for Syphilis
SUMMARY Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp. pallidum. Clinical manifestations separate the disease into stages; late stages of disease are now
Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis.
An enhanced T. pallidum strain typing system that shows biological and clinical relevance is described and is believed to be the most discriminating typing system.
Macrolide resistance in Treponema pallidum in the United States and Ireland.
An HIV-infected patient in San Francisco with primary syphilis was treated with azithromycin, but the lesion did not resolve, and a mutation in the 23S rRNA genes of T. pallidum was identified.
Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features.
Serum RPR titer helps predict the likelihood of neurosyphilis and HIV-induced immune impairment may increase the risk of neuroSyphilis.
Syphilis: using modern approaches to understand an old disease.
  • E. Ho, S. Lukehart
  • Biology, Medicine
    The Journal of clinical investigation
  • 1 December 2011
Recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks are reviewed.
Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response
Antibodies directed to purified recombinant variable domain of Tpr K can opsonize T. pallidum, Nichols strain, for phagocytosis, supporting the hypothesis that this portion of the protein is exposed at the surface of the treponeme.
Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens
It is reviewed how bacterial, protozoan and fungal pathogens from distant evolutionary lineages have evolved surprisingly similar mechanisms of antigenic variation to avoid eradication by the host immune system and can therefore maintain persistent infections and ensure their transmission to new hosts.
Genital ulceration as a risk factor for human immunodeficiency virus infection.
Aggressive control of chancroid and syphilis may offer one very feasible approach to reducing transmission of HIV in this region.
Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92.
It is demonstrated that Tp92 is an invariant, immunoprotective antigen that may be present on the surface of T. pallidum and may represent a potential vaccine candidate for syphilis.