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Identification and purification of calpactins from cardiac muscle and their effect on Na+/Ca2+ exchange activity.
Two major proteins able to bind phospholipids in a Ca2(+)-dependent manner completely reversed the inhibition of Na+/Ca2+ exchange activity of cardiac sarcolemmal vesicles consequent to EGTA-treatment. Expand
Effects of Canrenone on Aorta and Right Ventricle of the Rat
Inhibition of calcium entry through calcium channels either in aorta or ventricles is the most parsimonious hypothesis of mechanism underlying the effect of canrenone on contractile responses of rat aortA to agonists and high K+ and the negative inotropic effect on ventricular strips. Expand
Effect of amiloride on sodium-calcium exchange activity in rat cardiac myocytes.
The effect of amiloride on Na+/Ca2+ exchange activity and adenylate energy charge in isolated rat cardiac myocytes has been studied. Amiloride inhibits Na+/Ca2+ exchange activity in rat cardiacExpand
Effect of long-term ouabain treatment on contractile responses of rat aortae.
Male Sprague-Dawley rats were infused with 50 microg/kg/day of ouabain for 4 weeks to address the question whether prolonged exposure to the drug affects blood pressure, the in vitro contractileExpand
Inhibition by Atractyloside of the Binding of Adenine-nucleotides to Rat-liver Mitochondria
The competition between atractyloside and ADP on oxygen and phosphate uptake by mitochondria3 would seem to indicate that the effect of atractyoside is due to inhibition of the ADP utilizing process in the coupling system. Expand
Na/Ca exchange and tension development in vascular smooth muscle: effect of amiloride
The pattern of amiloride action on ouabain‐, low K‐ and Na‐free‐induced contractions suggests that the drug interferes with Ca influx, and it is suggested that amiles prevents Ca fluxes through the Na/Ca exchange system of guinea‐pig aortic strips. Expand
Effects of carboxyatractyloside a structural analogue of atractyloside on mitochondrial oxidative phosphorylation.
The behaviour of carboxyatractyloside on mitochondria resembles that of bonkrekic acid and it is uneffective on ATPase activity of sonicated mitochondrial particles whereas strongly inhibits translocation of adenine nucleotides across the mitochondrial membrane. Expand
Effects of chromium(VI) and chromium(III) on energy charge and oxygen consumption in rat thymocytes.
In rat thymocytes permeabilized with digitonin and in isolated rat liver mitochondria both Cr(VI) and Cr(III) showed a marked inhibition of maximal oxygen consumption rate (uncoupled respiration). Expand
Inhibition of cardiac sarcolemmal sodium-calcium exchanger by glycerophosphoinositol 4-phosphate and glycerophosphoinositol 4-5-bisphosphate.
The data indicate a bidirectional regulation of Na+/Ca2+ exchanger and suggest that phosphorylated glycerophosphoinositols can be regarded as novel signal transducers of intracellular Ca2+ regulation in heart cell. Expand
Effects of Atractyloside and Oligomycin on Magnesium-stimulated Adenosine Triphosphatase and on Adenosine Triphosphate-induced Contraction of Swollen Mitochondria
It was shown that atractyloside inhibits the energy-transfer reactions of oxidative phosphorylation in a manner similar to that of the antibiotic oligomycin2–4. Expand