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A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma
BackgroundThe esophageal carcinoma related gene 4 (ECRG4) was initially identified and cloned from human normal esophageal epithelium in our laboratory (GenBank accession no.AF325503). ECRG4 has been… Expand
Alterations of oncogenes and tumor suppressor genes in esophageal cancer in China.
- S. Lu
- Biology, Medicine
- Mutation research
- 1 April 2000
RFT2 is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenesis by sustaining cell proliferation and protecting against cell death.
Human riboflavin transporter 2 (RFT2, also termed as SLC52A3) was recently identified as a susceptibility gene to esophageal squamous cell carcinoma (ESCC), however, its expression and biologic… Expand
TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamous… Expand
Comprehensive prevention and treatment for esophageal cancer.
Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
Metformin is a widely used anti-diabetic drug for the management of type 2 diabetes mellitus. Recently, epidemiological studies demonstrate that metformin has anti-cancer effects on esophageal… Expand
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells
Cancer stem cells (CSCs) have been isolated from many tumors and considered as the main reason of cancer recurrence and metastasis. DNA methyltransferase 1 (DNMT1) mediates DNA methylation and plays… Expand