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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsicExpand
A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa.
The opportunistic pathogen Pseudomonas aeruginosa causes a variety of acute and chronic infections. We identified a gene whose inactivation results in attenuation of virulence due to prematureExpand
A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretionExpand
Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway.
Type III secretion systems (TTSSs) are utilized by numerous bacterial pathogens to inject effector proteins directly into host cells. Using a whole-genome microarray, we investigated the conditionsExpand
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
The opportunistic pathogen Pseudomonas aeruginosa is responsible for systemic infections in immunocompromised individuals and chronic respiratory disease in patients with cystic fibrosis. CyclicExpand
A four‐tiered transcriptional regulatory circuit controls flagellar biogenesis in Pseudomonas aeruginosa
The single polar flagellum of Pseudomonas aeruginosa is an important virulence and colonization factor of this opportunistic pathogen. In this study, the annotation of the genes belonging to the flaExpand
The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs
We report here the results of an analysis of the regulatory range of the GacS/GacA two‐component system in Pseudomonas aeruginosa. Using microarrays, we identified a large number of genes that areExpand
Structure-function and biogenesis of the type IV pili.
Type IV pili are adhesins expressed by a number of diverse gram-negative microorganisms. These pili are related through similarities in the primary amino acid sequences of the structural subunits, aExpand
Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.
The opportunistic pathogen Pseudomonas aeruginosa is responsible for a wide range of acute and chronic infections. The transition to chronic infections is accompanied by physiological changes in theExpand
Dynamics of Pseudomonas aeruginosa genome evolution
One of the hallmarks of the Gram-negative bacterium Pseudomonas aeruginosa is its ability to thrive in diverse environments that includes humans with a variety of debilitating diseases or immuneExpand