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Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to
TLDR
The absorption and disposition of 14C label were studied in male Sprague-Dawley rats following iv or dermal administration of KB 14C labelled in the carbonyl carbon of either KI or KII, indicating greater systemic penetration at higher concentrations. Expand
Influence of strain differences in mice on the metabolism and toxicity of benzene.
TLDR
It was concluded that the difference in susceptibility to benzene between C57BL6 and DBA2 mice was not the result of a single factor, buth rather, the sum total of a number of metabolic events. Expand
Toxicological and biochemical effects of repeated administration of benzene in mice.
TLDR
It is demonstrated that increasing benzene toxicity during repetitive treatment of mice is accompanied by increases in the levels of both water-soluble and covalently bound benzene metabolites. Expand
Metabolic correlates of benzene toxicity.
TLDR
It is concluded on the basis of several lines of evidence that benzene toxicity is due to the formation of a toxic metabolite of benzene. Expand
Urinary metabolites of benzene in the mouse.
TLDR
Chronic benzene toxicity, which is characterized by decreases in circulating blood cell levels due to depression of the bone marrow, is thought to be caused by a metabolite of benzene, mainly in the form of conjugated phenolic metabolites of Benzene. Expand
BENZENE METABOLISM AND TOXICITY IN CD-1, C57/B6, AND DBA/2N MICE
TLDR
A comparison of the metabolism of benzene with its toxicity in C57/B6, DBA/2N, and CD-I mice is presented, suggesting that metabolites of Benzene interact with critical functions of the rapidly proliferating cells of bone marrow. Expand
Occupational exposure to isothiazolinones
TLDR
It needs to be clarified that the product category 'preservatives' with an indicated concentration range of 0.1-3.5% (1000-35,000 ppm) for methylchloroisothiazolone/methylisothiazolate (MCI) refers to commercial concentrated solutions of MCI/MI, and that these 'preservative' are not end-use products like the other product categories listed in the article. Expand
Azacytidine‐induced reactivation of adenosine deaminase in a murine cytotoxic T cell line
TLDR
It is suggested that the extinction of the ADA gene which appears to be specific for CTL and to take place in vivo during T cell differenciation may result from increased methylation in or near theADA gene. Expand
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