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Growth and regeneration of adult beta cells does not involve specialized progenitors.
TLDR
A novel DNA analog-based lineage-tracing technique to detect multiple rounds of cell division in vivo is applied to determine the adult lineage mechanism of the insulin-secreting beta cells of pancreatic islets, an important unresolved question in diabetes research. Expand
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.
TLDR
It is shown that cyclins D2 and D1 are essential for normal postnatal islet growth in adult mice, and strategies to tightly regulate D-type cyclin activity in beta cells could prevent or cure diabetes. Expand
Very Slow Turnover of β-Cells in Aged Adult Mice
TLDR
It is shown that β-cells of aged adult mice have extremely low rates of replication, with minimal evidence of turnover, and it is concluded that adult β- cells are very long lived. Expand
Very slow turnover of beta-cells in aged adult mice.
TLDR
It is shown that beta-cells of aged adult mice have extremely low rates of replication, with minimal evidence of turnover, and it is concluded that adult beta- cells are very long lived. Expand
Review of Elephant Endotheliotropic Herpesviruses and Acute Hemorrhagic Disease.
TLDR
Researchers have not yet been able to propagate EEHV in cell culture, determine whether or not human antiherpesvirus drugs are effective inhibitors, or develop serology assays that can distinguish between antibodies against the multiple different EEhV species. Expand
Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth
TLDR
It is shown that cyclins D2 and D1 are essential for normal postnatal islet growth in adult mice, and strategies to tightly regulate D-type cyclin activity in β cells could prevent or cure diabetes. Expand
FATAL HERPESVIRUS HEMORRHAGIC DISEASE IN WILD AND ORPHAN ASIAN ELEPHANTS IN SOUTHERN INDIA
TLDR
The results argue against the previous suggestions that this is just a disease of captive elephants and that the EEHV1 virus has crossed recently from African elephant hosts to Asian elephants, and instead, both the virus and the disease are evidently widespread in Asia. Expand
The Murine Coronavirus Nucleocapsid Gene Is a Determinant of Virulence
ABSTRACT The murine coronavirus, mouse hepatitis virus (MHV) strain A59, causes acute encephalitis and chronic demyelinating disease as well as hepatitis in mice. The JHM strain (also called MHV-4 orExpand
Detection of Quiescent Infections with Multiple Elephant Endotheliotropic Herpesviruses (EEHVs), Including EEHV2, EEHV3, EEHV6, and EEHV7, within Lymphoid Lung Nodules or Lung and Spleen Tissue
TLDR
Genotype analyses by partial PCR sequencing of necropsy tissue from five asymptomatic African elephants and identified multiple simultaneous infections by several different EEHV types, including high concentrations in lymphoid lung nodules provide strong evidence that EEHHV2, EEHv3, EEhV6, and EEHWV7 represent natural ubiquitous infections in African elephants. Expand
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
TLDR
Data indicate that cyclin D2 is regulated by protein stability in pancreatic beta-cells, that signals that act upon threonine 280 limit cyclinD2 stability in beta- cells, and that threonines 280-mutant cyclin L2 overexpression prolongs beta- cell survival and augments beta-cell mass expansion. Expand
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