Structure of a cannabinoid receptor and functional expression of the cloned cDNA
The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.
Localization of cannabinoid receptor mRNA in rat brain
The localization of cannabinoid receptor mRNA indicates that sensory, motor, cognitive, limbic, and autonomic systems should all be influenced by the activation of this receptor by either exogenous cannabimimetics, including marijuana, or the yet unknown endogenous “cannabinoid” ligand.
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues
- G. Hazell, S. Yao, J. Roper, E. Prossnitz, A. O'Carroll, S. Lolait
- BiologyJournal of Endocrinology
- 5 May 2009
The distribution of GPR30 is distinct from the other traditional ERs and offers an additional way in which oestrogen may mediate its effects in numerous brain regions and endocrine systems in the rodent.
Comparative distribution of vasopressin V1b and oxytocin receptor messenger ribonucleic acids in brain.
The comparative distributions of the vasopressin V1b receptor (V1bR) and the oxytocin receptor (OTR) messenger RNAs (mRNAs) are described in male rat brain using in situ hybridization histochemistry to suggest functional specialization of the V 1b, OTR and V1a receptors in brain.
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
The physiological and pathological roles that support this system as a novel therapeutic target for pharmacological intervention in treating conditions related to altered water balance, stress-induced disorders such as anxiety and depression, and cardiovascular and metabolic disorders are highlighted.
Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin.
The distribution of the V1bR protein was investigated in the rat forebrain, midbrain, hindbrain, and cerebellum by immunohistochemistry using an antiserum raised against a synthetic fragment of the carboxylterminal of the rat V1BR protein to suggest that the V 1bR mediates different physiological functions of VP in the brain.
Cellular localization of vasopressin V1a receptor messenger ribonucleic acid in adult male rat brain, pineal, and brain vasculature.
The distribution of V1aR mRNA suggests that there are at least two types of vasopressin-responsive cells in brain: one type exemplified by lateral septal ara neurons innervated by classical axodendritic/somatic synaptic vasoppressinergic terminals and a second, perivascular/vascular type that would facilitate humoral vasOPressinergic signaling in the brain.
Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues.
- C. Owman, P. Blay, C. Nilsson, S. Lolait
- BiologyBiochemical and Biophysical Research…
- 12 November 1996
Receptor message was ubiquitously distributed in normal peripheral tissues and CNS, suggesting that CMKRL2 is expressed in widespread cell populations, such as macrophages and neuroglia.
Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus
- S. Lolait, A. O'Carroll, O. Mcbride, M. Konig, A. Morel, M. Brownstein
- Biology, MedicineNature
- 28 May 1992
The cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, and with similarity to the Via (hepatic) AVP receptors2 in its seven membrane-spanning domains is reported.
Extrapituitary expression of the rat V1b vasopressin receptor gene.
- S. Lolait, A. O'Carroll, M. Brownstein
- BiologyProceedings of the National Academy of Sciences…
- 18 July 1995
RNA blot analysis, reverse transcription PCR, and in situ hybridization studies reveal that V1b receptor mRNA is expressed in the majority of pituitary corticotropes as well as in multiple brain regions and a number of peripheral tissues, including kidney, thymus, heart, lung, spleen, uterus, and breast.