• Publications
  • Influence
High‐resolution genomic and expression analyses of copy number alterations in breast tumors
Analysis of recurrent DNA amplification can lead to the identification of cancer driver genes, but this process is often hampered by the low resolution of existing copy number analysis platforms.Expand
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Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach*
  • L. Gan, S. Ye, +11 authors R. Urfer
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 13 February 2004
Alzheimer's disease is a progressive neurodegenerative disease characterized by senile plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells. Activated microglia are foundExpand
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Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia‐induced gene expression patterns, and
In order to identify biological processes relevant for cell death and survival in the brain following stroke, the postischemic brain transcriptome was studied by a large‐scale cDNA array analysis ofExpand
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A role for receptor tyrosine phosphatase zeta in glioma cell migration.
Glioblastomas (GBM) are the most frequent and malignant human brain tumor type. Typically striking in adulthood, tumor progression is rapid, relentless, and ultimately leads to the patient's deathExpand
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Inferring the functional effects of mutation through clusters of mutations in homologous proteins
Inferring functional consequences is a bottleneck in high‐throughput cancer mutation discovery and genetic association studies. Most polymorphisms and germline mutations are unlikely to haveExpand
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A role for receptor tyrosine phosphataseζ in glioma cell migration
Glioblastomas (GBM) are the most frequent and malignant human brain tumor type. Typically striking in adulthood, tumor progression is rapid, relentless, and ultimately leads to the patient's deathExpand
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Predicting protein function from structure: unique structural features of proteases.
We have noted consistent structural similarities among unrelated proteases. In comparison with other proteins of similar size, proteases have smaller than average surface areas, smaller radii ofExpand
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Safety and tolerability of GRF6019 in mild‐to‐moderate Alzheimer's disease dementia
Abstract Introduction This phase 2 trial evaluated the safety, tolerability, and feasibility of repeated infusions of the plasma fraction GRF6019 in mild‐to‐moderate Alzheimer's disease. Methods InExpand
BENEFICIAL EFFECTS OF A PLASMA FRACTION ON NEUROGENESIS FOR AGE-RELATED COGNITIVE DISORDERS
Abstract The process of aging is multifactorial and therefore single interventions may be unlikely to attenuate the myriad pathologies. Plasma contains many beneficial factors which have been shownExpand