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Pressure Induced Deep Tissue Injury Explained
TLDR
A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals, which led to a clear understanding on two damage mechanisms associated with the development of DTI.
The effects of deformation, ischemia, and reperfusion on the development of muscle damage during prolonged loading.
TLDR
The results imply that deformation, ischemia, and reperfusion all contribute to the damage process during prolonged loading, although their importance varies with time.
Influence of dilated cardiomyopathy and a left ventricular assist device on vortex dynamics in the left ventricle
TLDR
The aim of this study was to develop a method to investigate the influence of a left ventricular assist device (LVAD) on vortex dynamics in a failing ventricle, and results show that the strength of the leading vortex ring is lower in a DCM Ventricle than in a healthy ventricles.
Temporal Effects of Mechanical Loading on Deformation-Induced Damage in Skeletal Muscle Tissue
TLDR
The data showed that a 2 h loading period caused more damage than 10 min loading and a local deformation threshold for damage was found, which was similar for each of the loading regimes applied in this study.
Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
TLDR
The hypothesis that integration of a computationally inspired heart valve design into TE methodologies could guide tissue remodeling toward long-term functionality in tissue-engineered heart valves (TEHVs) is tested and suggests the relevance of an integrated in silico, in vitro, and in vivo bioengineering approach as a basis for the safe and efficient clinical translation of TEHVs.
Improved Geometry of Decellularized Tissue Engineered Heart Valves to Prevent Leaflet Retraction
TLDR
An improved DTEHV is proposed that is expected to be less prone to host cell mediated leaflet retraction and will remain competent after implantation by using a constraining bioreactor insert during culture.
Computational model predicts cell orientation in response to a range of mechanical stimuli
TLDR
A computational model was developed which predicts cell orientation, based on the actin stress fiber distribution inside the cell, which predicts that on a substrate of anisotropic stiffness, fibers align in the stiffest direction.
Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo
TLDR
TEHV-geometry can significantly influence the host cell response by determining the infiltration and presence of macrophages and α-SMA+-cells, which play a crucial role in orchestrating TEHV remodeling.
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