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Antiretroviral regimens in pregnancy and breast-feeding in Botswana.
BACKGROUND The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during… Expand
Response to antiretroviral therapy after a single, peripartum dose of nevirapine.
BACKGROUND A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers… Expand
Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana.
- Jennifer Y. Chen, H. Ribaudo, +11 authors R. Shapiro
- The Journal of infectious diseases
- 1 December 2012
BACKGROUND It is unknown whether adverse birth outcomes are associated with maternal highly active antiretroviral therapy (HAART) in pregnancy, particularly in resource-limited settings. METHODS We… Expand
Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein1
- Shawn M. Sumida, D. Truitt, +15 authors D. Barouch
- Biology, Medicine
- The Journal of Immunology
- 1 June 2005
The utility of recombinant adenovirus serotype 5 (rAd5) vector-based vaccines for HIV-1 and other pathogens will likely be limited by the high prevalence of pre-existing Ad5-specific neutralizing Abs… Expand
Male circumcision: an acceptable strategy for HIV prevention in Botswana
Background: Male circumcision is known to reduce the risk of acquiring HIV, but few studies have been performed to assess its acceptability among either children or adults in sub-Saharan Africa.… Expand
Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the…
CONTEXT Postnatal transmission of human immunodeficiency virus-1 (HIV) via breastfeeding reverses gains achieved by perinatal antiretroviral interventions. OBJECTIVE To compare the efficacy and… Expand
Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancy.
BACKGROUND Protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) use in pregnancy has been associated with preterm deliveries in some observational studies. METHODS… Expand
Serum concentrations of antimycobacterial drugs in patients with pulmonary tuberculosis in Botswana.
- J. Tappero, W. Bradford, +9 authors C. Peloquin
- Clinical infectious diseases : an official…
- 15 August 2005
BACKGROUND We conducted a pharmacokinetic study of antimycobacterial drugs involving a cohort of patients with pulmonary tuberculosis (TB) in Gaborone, Botswana, to assess the prevalence of and risk… Expand
Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis.
OBJECTIVE Existing studies present conflicting evidence for the role of cigarette smoking as a risk factor in the development of systemic lupus erythematosus (SLE). We performed an extensive search… Expand
Botswana's progress toward achieving the 2020 UNAIDS 90-90-90 antiretroviral therapy and virological suppression goals: a population-based survey.
BACKGROUND HIV programmes face challenges achieving high rates of HIV testing and treatment needed to optimise health and to reduce transmission. We used data from the Botswana Combination Prevention… Expand