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Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
TLDR
Candida auris is an emerging healthcare-associated pathogen associated with high mortality, and WGS analysis suggests nearly simultaneous, and recent, independent emergence of different clonal populations on 3 continents.
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research
TLDR
These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk.
Geographic Distribution and Antifungal Susceptibility of the Newly Described Species Candida orthopsilosis and Candida metapsilosis in Comparison to the Closely Related Species Candida parapsilosis
TLDR
The species and antifungal susceptibilities of 1,929 invasive clinical isolates from the ARTEMIS antif fungus surveillance program collected between 2001 and 2006 and identified as C. parapsilosis using Vitek and conventional methods were determined.
Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011.
TLDR
Signs of marked shifts in candidemia epidemiology over the past 2 decades are described, with adults aged ≥65 years replaced infants as the highest incidence group and adjusted incidence has declined significantly in infants.
Declining Incidence of Candidemia and the Shifting Epidemiology of Candida Resistance in Two US Metropolitan Areas, 2008–2013: Results from Population-Based Surveillance
TLDR
A significant decline in the incidence of candidemia over a five-year period is observed, and increases in echinocandin-resistant and MDR Candida.
Parity among the randomly amplified polymorphic DNA method, multilocus enzyme electrophoresis, and Southern blot hybridization with the moderately repetitive DNA probe Ca3 for fingerprinting Candida
TLDR
The strong correlations demonstrated between polymorphic markers assessed by the four independent fingerprinting methods and the nonrandom association between loci demonstrated by RAPD analysis and MLEE provide evidence for strong linkage disequilibrium and a clonal population structure for C. albicans.
Frequency of Decreased Susceptibility and Resistance to Echinocandins among Fluconazole-Resistant Bloodstream Isolates of Candida glabrata
TLDR
These data document the broad emergence of coresistance over time to both azoles and echinocandins in clinical isolates of C. glabrata and suggest that the first-line treatment of bloodstream infections due to Candida glabRata is still the best option.
Antimicrobial Resistance among Gram-Negative Bacilli Causing Infections in Intensive Care Unit Patients in the United States between 1993 and 2004
TLDR
The prevalence of multidrug resistance, defined as resistance to at least one extended-spectrum cephalosporin, one aminoglycoside, and ciprofloxacin, increased substantially among ICU isolates of Acinetobacter spp.
Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene
TLDR
Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus.
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