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Automatic and quantitative measurement of protein-protein colocalization in live cells.
We introduce a novel statistical approach that quantifies, for the first time, the amount of colocalization of two fluorescent-labeled proteins in an image automatically, removing the bias of visualExpand
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
It is shown that senescent human fibroblasts stimulate premalignant and malignant, but not normal, epithelial cells to proliferate in culture and form tumors in mice, suggesting it is an example of evolutionary antagonistic pleiotropy. Expand
The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation
A yeast two-hybrid analysis revealed that Pdcd4 associates with the eukaryotic translation initiation factors eIF4AI and eIF 4AII, and the mechanism by which PdCD4 inhibits translation appears to involve inhibition of eif4A helicase, interference with eIF2A association-dissociation from eIF3G, and inhibition ofeIF4A binding to the C-terminal domain of eIF5G. Expand
Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane.
It is demonstrated that PI(4,5)P2 plays a key role in Gag targeting to the plasma membrane and thus serves as a cellular determinant of HIV-1 particle production. Expand
In situ analyses of genome instability in breast cancer
The data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ. Expand
Structural Protein 4.1 in the Nucleus of Human Cells: Dynamic Rearrangements during Cell Division
The results suggest that multiple protein 4.1 isoforms may contribute significantly to nuclear architecture and ultimately to nuclear function. Expand
Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3
This study describes a mutant mouse line that completely lacks SUMO1, but surprisingly is viable and lacks any overt phenotype, and points to compensatory utilization of SUMO2 and/or SUMO3 for sumoylation ofSumO1 targets. Expand
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.
In vitro growth characteristics of cells that exhibit either dormant or proliferative metastatic behavior in vivo are characterized and phosphorylation of myosin light chain by MLC kinase (MLCK) through integrin beta1 is required for actin stress fiber formation and proliferative growth. Expand
Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission
The ability of p8 to simultaneously anergize and cluster T cells, together with its induction of cellular conduits, secures virus propagation while avoiding the host's immune surveillance. Expand
High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis
This study provides answers to long-standing questions in HIV-1 biology and illustrates the power and sensitivity of the 2-RNA labeling method, which can also be adapted to analyze various issues of RNA biogenesis including the detection of different RNAs in live cell imaging. Expand