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The Fundamental Role of Pirouettes in Caenorhabditis elegans Chemotaxis
- J. Pierce-Shimomura, Thomas M. Morse, S. Lockery
- Biology, MedicineThe Journal of Neuroscience
- 1 November 1999
It is suggested that chemotaxis is produced by a series of pirouettes that reorient the animal to the gradient, and the pirouette model of C. elegans chemot axis is sufficient and general.
Active Currents Regulate Sensitivity and Dynamic Range in C. elegans Neurons
Functional asymmetry in Caenorhabditis elegans taste neurons and its computational role in chemotaxis
- Hiroshi Suzuki, T. Thiele, S. Faumont, Marina Ezcurra, S. Lockery, W. Schafer
- Biology, MedicineNature
- 3 July 2008
Recordings from synaptic and sensory transduction mutants show that the ON–OFF asymmetry is the result of intrinsic differences between ASE neurons, and evidence for ON and OFF cells in other chemosensory networks suggests that this motif may be common in animals that navigate by taste and smell.
Characterization of Drosophila Larval Crawling at the Level of Organism, Segment, and Somatic Body Wall Musculature
This work lays a foundation for use of Drosophila larva as a model system for studying the genetics and development of rhythmic behavior and quantified crawling at the organism, segment, and muscle levels.
Global Brain Dynamics Embed the Motor Command Sequence of Caenorhabditis elegans
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode
- Sarah Chang, R. Johnston, Christian Frøkjær-Jensen, S. Lockery, O. Hobert
- Biology, MedicineNature
- 12 August 2004
An inverse distribution of two sequentially acting miRNAs in two bilaterally symmetric neurons controls laterality of the nematode chemosensory system.
Searching for Neuronal Left/Right Asymmetry: Genomewide Analysis of Nematode Receptor-Type Guanylyl Cyclases
The results indicate theexistence of a surprising multitude of putative chemoreceptors in the gustatory ASE neurons and suggest the existence of a substantial degree of laterality in gustatory signaling mechanisms in nematodes.
Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
A minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior, suggesting that the model may be operating according to principles similar to those of the biological network.
Mutations in the Caenorhabditis elegans Na,K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function
- M. Davis, D. Somerville, R. Lee, S. Lockery, L. Avery, D. Fambrough
- Biology, MedicineThe Journal of neuroscience : the official…
- 1 December 1995
It is proposed that a Reduction of Na,K- ATPase activity in eat-6 mutants leads to a reduction of the ion concentration gradients that power membrane potential changes.
Artificial dirt: microfluidic substrates for nematode neurobiology and behavior.
- S. Lockery, K. J. Lawton, +7 authors B. Pruitt
- Biology, MedicineJournal of neurophysiology
- 1 June 2008
A new class of microfluidic devices for C. elegans neurobiology and behavior are presented: agarose-free, micron-scale chambers and channels that allow the animals to crawl as they would on agarOSE, likely to accelerate studies of the neuronal basis of behavior in this organism.