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Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
Due to their small size, nanoparticles have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology.Expand
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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression ofExpand
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Detailed identification of plasma proteins adsorbed on copolymer nanoparticles.
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Calcium binding to calmodulin and its globular domains.
The macroscopic Ca(2+)-binding constants of bovine calmodulin have been determined from titrations with Ca2+ in the presence of the chromophoric chelator 5,5'-Br2BAPTA in 0, 10, 25, 50, 100, and 150Expand
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Methods for the detection and analysis of protein-protein interactions.
A large number of methods have been developed over the years to study protein-protein interactions. Many of these techniques are now available to the nonspecialist researcher thanks to new affordableExpand
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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Significance Alzheimer's disease and several related disorders are associated with the assembly of specific proteins into ordered fibrillar aggregates. In Alzheimer's disease, the key component ofExpand
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Conversion of alpha-lactalbumin to a protein inducing apoptosis.
In this study alpha-lactalbumin was converted from the regular, native state to a folding variant with altered biological function. The folding variant was shown to induce apoptosis in tumor cellsExpand
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Nucleation of protein fibrillation by nanoparticles
Nanoparticles present enormous surface areas and are found to enhance the rate of protein fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many humanExpand
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Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex.
The transcription factor Rex has been implicated in regulation of the expression of genes important for fermentative growth and for growth under conditions of low oxygen tension in severalExpand
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The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century.
The major aim of our current work is to develop a deep understanding of biological effects of nanoparticles and how these effects are mediated by proteins that are adsorbed on the nanoparticles underExpand
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