• Publications
  • Influence
Structure and mechanism of carbonic anhydrase.
  • S. Lindskog
  • Chemistry, Medicine
  • Pharmacology & therapeutics
  • 1997
Carbonic anhydrase (CA; carbonate hydro-lyase, EC 4.2.1.1) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2+ H2O<-->HCO3(-)+H+. The enzyme is the target forExpand
  • 680
  • 28
Purification and properties of bovine erythrocyte carbonic anhydrase.
  • S. Lindskog
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 8 April 1960
Abstract 1. 1. A new method for the purification of bovine erythrocyte carbonic anhydrase is described. The procedure invo;ves chromatography on DEAE cellulose ion exchanger and zone electrophoresisExpand
  • 216
  • 5
Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant.
To test the hypothesis that histidine 64 in the active site of human carbonic anhydrase II functions as a proton-transfer group in the catalysis of CO2 hydration, we have studied a site-specificExpand
  • 295
  • 5
The complete sequence, expression in Escherichia coli, purification and some properties of carbonic anhydrase from Neisseria gonorrhoeae.
The complete nucleotide sequence of the carbonic anhydrase gene from Neisseria gonorrhoeae has been determined. The gene encodes a 252-residue polypeptide with a molecular mass of 28085 Da. The geneExpand
  • 84
  • 5
Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide.
The crystal structure of carbonic anhydrase from Neisseria gonorrhoeae has been solved to a resolution of 1.78 A by molecular replacement using human carbonic anhydrase II as a template. AfterExpand
  • 73
  • 5
The catalytic mechanism of mammalian carbonic anhydrases.
The physiological reaction catalyzed by carbonic anhydrase (CA) involves only six atoms at the substrate level: CO2 + H2O ↔ HCO 3 – + H+ Despite this simplicity, some aspects of the catalyticExpand
  • 76
  • 4
Cloning, expression and some properties of α-carbonic anhydrase from Helicobacter pylori
The -carbonic anhydrase gene from Helicobacter pylori strain 26695 has been cloned and sequenced. The full-length protein appears to be toxic to Escherichia coli, so we prepared a modified form of ...
  • 53
  • 4
METAL-BINDING PROPERTIES OF HUMAN ERYTHROCYTE CARBONIC ANHYDRASES.
Abstract 1. 1. The zinc ion can be reversibly removed from both high specific activity (C) and low specific activity (B) carbonic anhydrases (carbonate hydro-lyase, EC 4.2.1.1) of human red bloodExpand
  • 190
  • 3
The catalytic mechanism of carbonic anhydrase.
  • S. Lindskog, J. Coleman
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 November 1975
It is shown that an "inverse" relationship between the pH dependencies of the rates of hydration of CO(2) and dehydration of HCO(3) (-) by carbonic anhydrase (EC 4.2.1.1) is a direct consequence ofExpand
  • 333
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