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Differentiation between Cell Death Modes Using Measurements of Different Soluble Forms of Extracellular Cytokeratin 18
TLDR
It is reported that soluble cytokeratin-18 (CK18) is released from human carcinoma cells during cell death, and cell death of epithelially derived tumors can be assessed in patient serum, suggesting that tumor apoptosis may not necessarily be the dominating death mode in many tumors in vivo. Expand
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
TLDR
Treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model, showing that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target. Expand
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
TLDR
Preclinical data showing efficacy of b-AP15 in MM disease models validates targeting DUBs in the ubiquitin proteasomal cascade to overcome proteasome inhibitor resistance and provides the framework for clinical evaluation of USP14/UCHL5 inhibitors to improve patient outcome in MM. Expand
Deubiquitinase inhibition as a cancer therapeutic strategy.
TLDR
An overall review of DUBs relevant to cancer and of various small molecules which have been demonstrated to inhibit DUB activity is provided. Expand
Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling*
TLDR
It is demonstrated here that cisplatin-induced apoptotic signaling may occur independently of DNA damage, and this result has implications for the understanding of resistance mechanisms as well as the unique efficiency of this drug. Expand
Calpain-Mediated Bid Cleavage and Calpain-Independent Bak Modulation: Two Separate Pathways in Cisplatin-Induced Apoptosis
TLDR
Calpain-mediated Bid cleavage is important in drug-induced apoptosis, and cisplatin induces at least two separate apoptotic signaling pathways resulting in Bid cleaved and Bak modulation, respectively. Expand
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA
TLDR
It is proposed that the antiproliferative effects of cisplatin at IC50 doses involve premature senescence and secondary, nonstress‐induced apoptosis, which is largely DNA damage‐independent. Expand
Alterations in the Cellular Immune Compartment of Patients Treated with Third‐Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation
TLDR
There were several indications that MSCs shift the patients' immune system toward a more tolerogenic profile and the findings will contribute to the refinement of monitoring tools, for assessing MSC treatment‐efficacy and increase the understanding regarding the MSC's in vivo effects. Expand
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
TLDR
It is reported that the FDA-approved anthelmintic drug nitazoxanide could be a potential candidate for advancement into cancer clinical trials and it is shown that all five compounds inhibit mitochondrial respiration, suggesting that cancer cells in low glucose concentrations depend on oxidative phosphorylation rather than solely glycolysis. Expand
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
TLDR
The small molecule VLX600 is identified as a drug that is preferentially active against quiescent cells in colon cancer 3-D microtissues and displays tumour growth inhibition in vivo, suggesting that tumours in metabolically compromised microenvironments have a limited ability to respond to decreased mitochondrial function. Expand
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