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Angiogenesis: regulators and clinical applications.
Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties.
A negative feedback regulation by CD26/DPP IV in CX CR3-mediated chemotaxis without affecting the angiostatic potential of the CXCR3 ligands IP-10 and Mig is demonstrated.
The dual role of thymidine phosphorylase in cancer development and chemotherapy
- A. Bronckaers, F. Gago, J. Balzarini, S. Liekens
- Biology, MedicineMedicinal research reviews
- 11 May 2009
Clinical trials that combine cape citabine with TP‐inducing therapies (such as taxanes or radiotherapy) suggest that increasing TP expression is an adequate strategy to enhance the antitumoral efficacy of capecitabine.
CXCR3 ligands in disease and therapy.
CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.
CXCR4 inhibitors may be utilized to inhibit HIV-1 infection, tumor growth and metastasis and to mobilize hematopoietic stem cells from the bone marrow in the circulation, where they can be collected for autologous stem cell transplantation.
Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy.
Zebrafish Bioassay-Guided Natural Product Discovery: Isolation of Angiogenesis Inhibitors from East African Medicinal Plants
The results suggest that the combination of zebrafish bioassays with analytical chromatography methods is an effective strategy for the rapid identification of bioactive natural products.
Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine*
- J. Vande Voorde, S. Sabuncuoglu, S. Liekens
- Medicine, BiologyThe Journal of Biological Chemistry
- 25 March 2014
The findings suggest that the presence of mycoplasmas in the tumor microenvironment could be a limiting factor for the anticancer efficiency of dFdC-based chemotherapy.
Engineering of a Single Conserved Amino Acid Residue of Herpes Simplex Virus Type 1 Thymidine Kinase Allows a Predominant Shift from Pyrimidine to Purine Nucleoside Phosphorylation*
- J. Balzarini, S. Liekens, N. Solaroli, K. El Omari, D. Stammers, A. Karlsson
- Biology, ChemistryJournal of Biological Chemistry
- 14 July 2006
This work has shown that site-directed mutagenesis of the conserved Ala-167 and Ala-168 residues in HSV-1 TK resulted in a wide variety of differential affinities and catalytic activities in the presence of the natural substrate dThd and the purine nucleoside analogue drug ganciclovir (GCV), depending on the nature of the amino acid mutation.