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Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells
TLDR
The efficient conversion of human adult bone marrow stromal cells (hMSC) into a neural stem cell-like population (hmNSC, for human marrow-derived NSC-like cells) is described and it is demonstrated that individual hmNSCs are multipotent and retain the capacity to generate both glia and neurons.
Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols
TLDR
Evaluating various epigenetic conversion protocols using quantitative RT‐PCR and immunocytochemistry provides an impetus for differentiating hMSCs in vitro into mature neuroectodermal cells, which may ultimately help in treating acute and chronic neurodegenerative diseases.
Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation
TLDR
Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation, and co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription.
4‐Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient‐Derived Induced Pluripotent Stem Cells
TLDR
Treatment with the FDA approved drug 4‐Aminopyridine (4AP) restored ion‐channel imbalances, increased neuronal activity levels and decreased ER stress and caspase activation in patient‐derived MNs affected by ALS.
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
TLDR
The data identify the human pancreas as a target of SARS-CoV-2 infection and suggest that β-cell infection could contribute to the metabolic dysregulation observed in patients with COVID-19.
Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation
TLDR
Findings underline the regulatory role of K+ channels on the cell cycle and imply that K+ channel modulators might be used therapeutically to activate endogenous NPCs.
Formation and characterisation of neuromuscular junctions between hiPSC derived motoneurons and myotubes.
TLDR
The successful generation of an iPS cell derived functional cellular system consisting of two distinct communicating cells types could contribute to research on diseases in which the motoneurons and the NMJ are predominantly affected, such as in amyotrophic lateral sclerosis or spinal muscular atrophy.
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
TLDR
The retina-on-a-chip (RoC) is presented, a novel microphysiological model of the human retina integrating more than seven different essential retinal cell types derived from hiPSCs that provides vasculature-like perfusion and enables, for the first time, the recapitulation of the interaction of mature photoreceptor segments with RPE in vitro.
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