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Lymphoid organ development: from ontogeny to neogenesis

The development of lymphoid organs can be viewed as a continuum, including lymph nodes and spleen, which are genetically 'preprogrammed' and 'prepatterned' during ontogeny, whereas tertiary lymphoids organs arise under environmental influences and are not restricted to specific developmental 'windows' or anatomic locations.
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Synchrony of High Endothelial Venules and Lymphatic Vessels Revealed by Immunization1

The concordance in time and function and the close physical contact between LVs and HEVs in the remodeling process after immunization indicate that the two vascular systems are in synchrony and engage in cross-talk through B cells and LTβR.
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Impaired lymphatic contraction associated with immunosuppression

The suppression of lymphatic function by the CD11b+Gr-1+ cells is suggested as a potential mechanism of self-protection from autoreactive responses during on-going inflammation and suggests that other diseases such as cancer and infection may also mediate lymphatic contraction and thus immune response.
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TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

TGF-β blockade improved the intratumoral penetration of both a low-molecular-weight conventional chemotherapeutic drug and a nanotherape therapeutic agent, leading to better control of tumor growth.
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I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue.

A critical role for IKKalpha is revealed in LN and NALT development, GlyCAM-1 and high endothelial cell sulfotransferase are identified as new IKK alpha-dependent target genes, and it is suggested that LTbetaR signaling on HEV can regulate HEV-specific gene expression.
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Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells

The durability of hiPS-derived blood vessels in vivo demonstrates a potential translation of this approach in long-term vascularization for tissue engineering and treatment of vascular diseases and proof of the principle that autologous hiPS cell-derived vascular precursors can be used for in vivo applications.
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Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.

It is shown that implanted vascular networks anastomose with host vessels through a previously unidentified process of "wrapping and tapping" between the engrafted endothelial cells (ECs) and the host vasculature.
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PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer

PDGF-D is highly expressed in human breast cancer and facilitates tumor growth and lymph node metastasis, making it a potential target in breast cancer, at the same time, PDGF- D increases drug delivery and hence improves the efficacy of chemotherapy through vessel normalization.
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Mechanobiological oscillators control lymph flow

This model predicts that the Ca2+ and NO levels alternate spatiotemporally, establishing complementary feedback loops, and that the resulting phasic contractions drive lymph flow, allowing the lymphatic vessels to provide pumping when needed but remain open when flow can be driven by tissue pressure or gravity.
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Lymphatic system: an active pathway for immune protection.

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