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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.
IL-1 is a proinflammatory cytokine that signals through a receptor complex of two different transmembrane chains to generate multiple cellular responses, including activation of the transcription… Expand
Immune response in Stat2 knockout mice.
Type I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also transduce signals for… Expand
Artificial Intelligence Forecasting of Covid-19 in China
BACKGROUND An alternative to epidemiological models for transmission dynamics of Covid-19 in China, we propose the artificial intelligence (AI)-inspired methods for real-time forecasting of Covid-19… Expand
The Response Regulator PhoP Is Important for Survival under Conditions of Macrophage-Induced Stress and Virulence in Yersinia pestis
ABSTRACT The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been… Expand
Construction and characterization of a Yersinia enterocolitica O:8 high-temperature requirement (htrA) isogenic mutant.
- S. Li, N. Dorrell, P. H. Everest, G. Dougan, B. Wren
- Biology, Medicine
- Infection and immunity
- 1 June 1996
The high-temperature requirement (HtrA) family of stress response proteins are induced by different environmental stress conditions in a variety of bacteria and have been shown to contribute to the… Expand
High frequency of extrapair fertilization in a plural breeding bird, the Mexican jay, revealed by DNA microsatellites
We used tetra-nucleotide microsatellite DNA typing to estimate the frequency of extrapair fertilization (EPF) in a plural breeding species, the Mexican jay, Aphelocoma ultramarina, in Arizona. We… Expand
ASSOCIATION OF GENETIC VARIANT OF THE GLUCOSE TRANSPORTER WITH NON-INSULIN-DEPENDENT DIABETES MELLITUS
A DNA sequence polymorphism, revealed by digestion of genomic DNA with the endonuclease Xba1 and hybridisation with a complementary DNA clone for a human glucose transporter, yields two alleles… Expand
Construction and characterisation of a Yersinia enterocolitica O:8 ompR mutant.
- N. Dorrell, S. Li, P. H. Everest, G. Dougan, B. Wren
- Medicine, Biology
- FEMS microbiology letters
- 1 August 1998
The ompR-envZ two-component regulatory system has been shown to contribute to virulence in a number of enteric bacterial pathogens. A Yersinia enterocolitica O:8 ompR homologue was amplified, cloned… Expand
Elevated levels of RanBP7 mRNA in colorectal carcinoma are associated with increased proliferation and are similar to the transcription pattern of the proto-oncogene c-myc.
- S. Li, V. G. Gyselman, S. Dorudi, S. Bustin
- Biology, Medicine
- Biochemical and biophysical research…
- 10 May 2000
We have used suppression subtractive hybridisation, "in silico" cloning and reverse Northern dot blot analysis to identify significant up-regulation of RanBP7 transcription in a human colorectal… Expand
Forecasting and evaluating intervention of Covid-19 in the World
When the Covid-19 pandemic enters dangerous new phase, whether and when to take aggressive public health interventions to slow down the spread of COVID-19. To develop the artificial intelligence (AI)… Expand