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methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene regulation,cellular specification and cancer development. Here, we describe an R package, methylKit, thatrapidlyExpand
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The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p
The Saccharomyces cerevisiae Sln1 protein is a ‘two‐component’ regulator involved in osmotolerance. Two‐component regulators are a family of signal‐transduction molecules with histidine kinaseExpand
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The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase.
Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrialExpand
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Occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants.
The occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds (LPhACs), such as antibiotics (roxithromycin, erythromycin and ketoconazole), anti-inflammatoriesExpand
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Isoform-specific antagonists of exchange proteins directly activated by cAMP
The major physiological effects of cAMP in mammalian cells are transduced by two ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange protein directly activated byExpand
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Crystal structure of the Lassa virus nucleoprotein–RNA complex reveals a gating mechanism for RNA binding
Arenaviruses cause disease in industrialized and developing nations alike. Among them, the hemorrhagic fever virus Lassa is responsible for ∼300,000–500,000 infections/y in Western Africa. TheExpand
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Vibrio cholerae toxin-coregulated pilus structure analyzed by hydrogen/deuterium exchange mass spectrometry.
The bacterial pathogen Vibrio cholerae uses toxin-coregulated pili (TCP) to colonize the human intestine, causing the severe diarrheal disease cholera. TCP are long, thin, flexible homopolymers ofExpand
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Structural basis of the day-night transition in a bacterial circadian clock
Molecular clockwork from cyanobacteria The cyanobacterial circadian clock oscillator can be reconstituted in a test tube from just three proteins—KaiA, KaiB, and KaiC—and adenosine triphosphateExpand
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Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression
Ebolavirus causes a severe hemorrhagic fever and is divided into five distinct species, of which Reston ebolavirus is uniquely nonpathogenic to humans. Disease caused by ebolavirus is marked by earlyExpand
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The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p.
The yeast "two-component" osmotic stress phosphorelay consists of the histidine kinase, Sln1p, the phosphorelay intermediate, Ypd1p and two response regulators, Ssk1p and Skn7p, whose activities areExpand
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