• Publications
  • Influence
Targeting C-reactive protein for the treatment of cardiovascular disease
Therapeutic inhibition of CRP is a promising new approach to cardioprotection in acute myocardial infarction and may also provide neuroprotection in stroke and potential wider applications include other inflammatory, infective and tissue-damaging conditions characterized by increased CRP production. Expand
Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
Centrosomes associate with spindle poles; thus, the presence of two centrosomes promotes bipolar spindle assembly in normal cells, and the discovery of an allosteric inhibitor of HSET, CW069, which is designed using a methodology on an interface of chemistry and biology to pave the way for new cancer therapeutics. Expand
Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme
It is shown here that RAR signaling regulates choroid fissure closure in zebrafish by acting on both the ventral optic cup and the POM, and two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. Expand
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae
The results showed that hydrogenation of the C‐22,23 double bond did not decrease antifeedant activity and the nature of the substitutes at C‐1, C‐3 and C‐11 were important. Expand
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae
Generally, larvae were less sensitive to compounds when they were topically applied than when they was cannulated into the gut or injected into the haemolymph. Expand
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing
A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attachedExpand
Actions of azadirachtin, a plant allelochemical, against insects
Binding studies on locust testes and Spodoptera Sf9 cells have shown that the competitive binding of the different analogues of azadirachtin to these binding sites occurs in a similar order of potency to that found with antifeedant and IGR bioassays, suggesting a causal link between specific binding to membrane proteins and the ability of the molecule to exert biological effects. Expand
Sexual development of malaria parasites is inhibited in vitro by the neem extract azadirachtin, and its semi-synthetic analogues.
We have shown that azadirachtin, a compound from the neem tree, Azadirachta indica, and selected semi-synthetic derivatives, block the development of the motile male malarial gamete in vitro. ChangesExpand
Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.
This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCat) under microwave irradiation that enables a lower than normal bulk temperature to be maintained throughout the reaction period leading to significant improvements in the overall yield and purity of the reaction products. Expand