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Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg. Expand
Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths
There is conclusive evidence from randomised trials that statins substantially reduce not only coronary event rates but also total stroke rates in patients with a wide range of ages and blood pressures. Expand
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.
Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI. Expand
Diabetes mellitus, fasting glucose, and risk of cause-specific death.
In addition to vascular disease, diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors. Expand
Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents
The associations of both overweight and obesity with higher all-cause mortality were broadly consistent in four continents and supports strategies to combat the entire spectrum of excess adiposity in many populations. Expand
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis.
CONTEXT Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke. OBJECTIVE To assess the relationships of fibrinogen levels with risk of major vascularExpand
Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies.
The analyses were based on biennial remeasurements over 30 years for participants in the Framingham Study and a 26-year resurvey for a sample of men in the Whitehall Study and show that uncorrected associations of disease risk with baseline measurements underestimate the strength of the real associations with usual levels of these risk factors during the first decade of exposure. Expand
Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016, indicating that the burden of stroke is likely to remain high. Expand
Homocysteine, MTHFR and risk of venous thrombosis: a meta‐analysis of published epidemiological studies
This meta‐analysis of prospective and retrospective studies demonstrates a modest association of homocysteine with venous thrombosis and provides some support for causality with the MTHFR 677TT genotype. Expand