• Publications
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Antibacterial resistance worldwide: causes, challenges and responses
The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria areExpand
Molecular Mechanisms of Antibacterial Multidrug Resistance
Treatment of infections is compromised worldwide by the emergence of bacteria that are resistant to multiple antibiotics. Although classically attributed to chromosomal mutations, resistance is mostExpand
Food Animals and Antimicrobials: Impacts on Human Health
The substantial and expanding volume of evidence reporting animal-to-human spread of resistant bacteria, including that arising from use of NTAs, supports eliminating NTA use in order to reduce the growing environmental load of resistance genes. Expand
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 Å resolution
This is the first reported crystal structure of a member of this newly-described MarR protein family, which shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. Expand
Triclosan targets lipid synthesis
It is shown that triclosan blocks lipid synthesis in Escherichia coli, and that mutations in, or overexpression of, the gene fabI (which encodes enoyl reductase, involved in fatty acid synthesis) prevents this blockage. Expand
The challenge of antibiotic resistance.
  • S. Levy
  • Medicine
  • Scientific American
  • 1 March 1998
Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon
These studies extended the spectrum of inducers to include acetaminophen, sodium benzoate, 2,4-dinitrophenol (an uncoupling agent), and cinnamate (a salicylate precursor in plants) as well as inducers of the marRAB operon, which appears to contribute to the Mar phenotype in some strains. Expand
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli
The nature of the Mar mutations and the results of the complementation studies suggest that ORF125/144 encodes a repressor (designated MarR) which acts at marO, which reduced the antibiotic resistance of a Mar mutant to levels comparable to those of wild-type cells. Expand
Salicylate induction of antibiotic resistance in Escherichia coli: activation of the mar operon and a mar-independent pathway
Both in wild-type and mar-deficient strains, growth in salicylate resulted in increased antibiotic resistance, decreased permeation of the outer membrane to cephaloridine, increased micF transcription, and decreased amounts of OmpF, however, the magnitude of these changes was generally greater inWild-type (mar-containing) cells. Expand
Pseudomonas genomes: diverse and adaptable.
Members of the genus Pseudomonas inhabit a wide variety of environments, which is reflected in their versatile metabolic capacity and broad potential for adaptation to fluctuating environmentalExpand