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- Publications
- Influence
Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal
- Alexandre Surget, M. Saxe, S. Leman, Y. Ibarguen-Vargas, C. Belzung
- Psychology, Medicine
- Biological Psychiatry
- 15 August 2008
BACKGROUND
Depression and anxiety disorders have been linked to dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis and structural changes within the hippocampus. Unpredictable chronic mild… Expand
Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress
- Y. Ibarguen-Vargas, Alexandre Surget, P. Vourc'h, S. Leman, C. Belzung
- Psychology, Medicine
- Behavioural Brain Research
- 14 September 2009
Despite growing evidences of an association between brain-derived neurotrophic factor (BDNF) and antidepressant effects, the neurotrophic hypothesis of depression is challenged by the paucity of… Expand
Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression
- M. Nollet, P. Gaillard, F. Minier, A. Tanti, S. Leman
- Medicine
- Neuropharmacology
- 1 July 2011
Chronic stressful life events are risk factors for depression often accompanied by homeostatic disturbances. Hypothalamic neuropeptides, such as orexins (OXs) and melanin-concentrating hormone (MCH),… Expand
n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice Published, JLR Papers in Press, November 8, 2007.
- S. Vancassel, S. Leman, +7 authors S. Chalon
- Biology, Medicine
- Journal of Lipid Research
- 1 February 2008
The aim of this study was to examine the effects of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on stress responses in mice subjected to an unpredictable chronic mild stress (UCMS)… Expand
Activation of ventrolateral medullary neurons projecting to spinal autonomic areas after chemical stimulation of the central nucleus of amygdala: a neuroanatomical study in the rat
- Nicolas Salomé, O. Viltart, S. Leman, H. Sequeira
- Chemistry, Medicine
- Brain Research
- 2 February 2001
Several studies have shown that the central nucleus of amygdala is involved in cardiovascular regulation. The control of this function may be mediated by activation of the ventrolateral medulla… Expand
Effect of dorsal periaqueductal gray lesions on cardiovascular and behavioral responses to cat odor exposure in rats
- R. Dielenberg, S. Leman, P. Carrive
- Medicine
- Behavioural Brain Research
- 31 August 2004
Previously we demonstrated Fos expression in the dorsal periaqueductal gray (DPAG) of the rat following cat odor exposure. Further work correlated the response to cat odor with a sustained blood… Expand
Rodent models for autism: A critical review
- C. Belzung, S. Leman, P. Vourc'h, C. Andres
- Psychology
- 1 June 2005
We review 15 rodent models proposed for exploring autistic behaviours. There are two main types of behavioural tests that are relevant to autism, these include tests of social behaviour and… Expand
Neuroinflammation and depression: A review
- Romain Troubat, P. Barone, +8 authors V. Camus
- Medicine
- The European journal of neuroscience
- 9 March 2020
Some recent clinical and preclinical evidence suggests that neuroinflammation is a key factor that interacts with the three neurobiological correlates of major depressive disorder: depletion of brain… Expand
Expression of cardiovascular and behavioural components of conditioned fear to context in T4 spinally transected rats
- E. A. Choi, S. Leman, D. M. Vianna, P. Waite, P. Carrive
- Psychology, Medicine
- Autonomic Neuroscience
- 15 June 2005
A spinal cord transection at the fourth thoracic level (T4) results in paraplegia. It also removes supraspinal control of sympathetic outflow to most viscera and their blood vessels but spares the… Expand
Effect of dorsal periaqueductal gray lesion on cardiovascular and behavioural responses to contextual conditioned fear in rats
- S. Leman, R. Dielenberg, P. Carrive
- Psychology, Medicine
- Behavioural Brain Research
- 14 August 2003
Contextual conditioned fear in the rat is characterized by a freezing immobility associated with a marked increase in blood pressure, a slow increase in heart rate, and ultrasonic vocalizations. A… Expand