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ECM remodeling in hypertensive heart disease.
Hypertensive heart disease (HHD) occurs in patients that clinically have both diastolic and systolic heart failure and will soon become the most common cause of heart failure. Two key aspects ofExpand
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  • Open Access
Cellular mechanics and gene expression in blood vessels.
Blood vessels are permanently subjected to mechanical forces in the form of stretch, encompassing cyclic mechanical strain due to the pulsatile nature of blood flow, and shear stress. Alterations inExpand
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p47phox-Dependent NADPH Oxidase Regulates Flow-Induced Vascular Remodeling
Chronic alterations in blood flow elicit an adaptive response that tends to normalize shear stress, involving nitric oxide (NO) and matrix metalloproteinases (MMPs). To evaluate the role of NADPHExpand
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  • Open Access
Molecular mechanisms of the vascular responses to haemodynamic forces.
Blood vessels are permanently subjected to mechanical forces in the form of stretch, encompassing cyclic mechanical strain due to the pulsatile nature of blood flow and shear stress. SignificantExpand
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Role of matrix metalloproteinases in blood flow-induced arterial enlargement: interaction with NO.
Tears in the internal elastic lamina (IEL) can be observed after chronic increases in arterial blood flow, suggesting a potential role for matrix metalloproteinases (MMPs) in flow-induced vascularExpand
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Microparticles From Human Atherosclerotic Plaques Promote Endothelial ICAM-1–Dependent Monocyte Adhesion and Transendothelial Migration
Rationale and Objective: Membrane-shed submicron microparticles (MPs) released following cell activation or apoptosis accumulate in atherosclerotic plaques, where they stimulate endothelialExpand
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The endothelium: physiological functions and role in microcirculatory failure during severe sepsis
The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenanceExpand
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  • Open Access
Signal transduction of mechanical stresses in the vascular wall.
The vascular wall is constantly subjected to a variety of mechanical forces in the form of stretch (tensile stress), due to blood pressure, and shear stress, due to blood flow. Alterations in eitherExpand
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  • Open Access
Extracellular matrix alterations in hypertensive vascular remodeling.
Vascular cells are very sensitive to their hemodynamic environment. Any change in blood pressure or blood flow can be sensed by endothelial and vascular smooth muscle cells and ultimately results inExpand
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Shear Stress Regulates Endothelial Microparticle Release
Rationale: Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. Objective: Because laminar shear stress (SS) is a majorExpand
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  • Open Access