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- Publications
- Influence
Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
- Z. Chen, H. Kim, +13 authors A. M. Choi
- Chemistry, Medicine
- PloS one
- 2 October 2008
Background Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow… Expand
Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1
Cigarette smoke-induced cell death contributes to the pathogenesis of chronic obstructive pulmonary disease, though the relative roles of apoptosis and autophagy remain unclear. The inducible stress… Expand
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
- S. Lee, A. Smith, +12 authors A. Choi
- Biology, Medicine
- American journal of respiratory and critical care…
- 1 March 2011
RATIONALE
Pulmonary hypertension (PH) is a progressive disease with unclear etiology. The significance of autophagy in PH remains unknown.
OBJECTIVES
To determine the mechanisms by which autophagic… Expand
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
- Z. Chen, H. Lam, +7 authors A. Choi
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 October 2010
Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigarette smoke (CS), which involves airway obstruction and alveolar loss (i.e., emphysema). The… Expand
Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.
- S. Lee, Se-Kyung Bai, +9 authors Y. Kim
- Biology, Medicine
- Molecules and cells
- 31 August 2003
Astaxanthin, a carotenoid without vitamin A activity, has shown anti-oxidant and anti-inflammatory activities; however, its molecular action and mechanism have not been elucidated. We examined in… Expand
β-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-κB activation
- Se-Kyung Bai, S. Lee, +6 authors Y. Kim
- Chemistry
- Experimental & Molecular Medicine
- 31 August 2005
β-Carotene has shown antioxidant and antiinflammatory activities; however, its molecular mechanism has not been clearly defined. We examined in vitro and in vivo regulatory function of β-carotene on… Expand
Collagen Triple Helix Repeat Containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells
Collagen triple helix repeat-containing 1 (CTHRC1) is known to be aberrantly upregulated in most human solid tumors, although the functional roles of CTHRC1 in colorectal cancer remain unclear. In… Expand
Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death.
- A. Tanaka, Yang Jin, +5 authors A. Choi
- Biology, Medicine
- American journal of respiratory cell and…
- 14 December 2012
Epithelial cell death plays a critical role in hyperoxia-induced lung injury. We investigated the involvement of the autophagic marker microtubule-associated protein-1 light chain-3B (LC3B) in… Expand
Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
- S. Ryter, S. Lee, A. M. Choi
- Medicine
- Expert review of respiratory medicine
- 1 October 2010
The molecular and cellular mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD) remain incompletely understood. We have investigated the potential role of… Expand
beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation.
- Se-Kyung Bai, S. Lee, +6 authors Y. Kim
- Medicine
- Experimental & molecular medicine
- 2005
beta-Carotene has shown antioxidant and anti-inflammatory activities; however, its molecular mechanism has not been clearly defined. We examined in vitro and in vivo regulatory function of… Expand