• Publications
  • Influence
T lymphocytes negatively regulate lymph node lymphatic vessel formation.
Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelialExpand
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A Protease-Activated Pathway Underlying Th Cell Type 2 Activation and Allergic Lung Disease1
The respiratory allergens that induce experimental Th cell type 2-dependent allergic lung inflammation may be grouped into two functional classes. One class of allergens, in this study termed type I,Expand
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Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines
The mechanisms that initiate allergic lung inflammation are relevant to expression of diseases such as asthma, but the factors underlying resolution of inflammation are equally important. Previously,Expand
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Innate type 2 immunity is associated with eosinophilic pleural effusion in primary spontaneous pneumothorax.
RATIONALE Eosinophilic pleural effusion (EPE) is characterized by greater than 10% eosinophilia and is frequently associated with air and/or blood in the pleural cavity. Primary spontaneousExpand
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Differential requirement for CD18 in T-helper effector homing
To understand the integrin requirements of T-helper (TH) effector subsets, we investigated the contribution of CD18 (β2 integrin) to TH1 and TH2 function in vitro and in relevant disease models.Expand
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TH2 cells and their cytokines regulate formation and function of lymphatic vessels.
Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how theExpand
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Homing alone? CD18 in infectious and allergic disease.
  • S. Lee, D. Corry
  • Medicine, Biology
  • Trends in molecular medicine
  • 1 June 2004
CD18 (integrin β2) is an adhesion molecule that is crucial for host defense, but a comprehensive understanding of CD18 in immunity has been elusive. Studies now show that, through the control ofExpand
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Natural killer cells regulate eosinophilic inflammation in chronic rhinosinusitis
Eosinophils play a major pathologic role in the pathogenesis of diverse inflammatory diseases including chronic rhinosinusitis (CRS). Dysregulated production of prostaglandin (PG), particularly PGD2,Expand
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Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells.
Drug-induced liver injury (DILI) is a leading cause of liver disease and a key safety factor during drug development. In addition to the initiation events of drug-specific hepatotoxicity,Expand
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Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease
Background Tobacco-related lung diseases, including chronic obstructive pulmonary disease (COPD), are major causes of lung-related disability andExpand
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