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Interplay between Na+/Ca2+ Exchangers and Mitochondria in Ca2+ Clearance at the Calyx of Held
The clearance of Ca2+ from nerve terminals is critical for determining the build-up of residual Ca2+ after repetitive presynaptic activity. We found previously that K+-dependent Na+/Ca2+ exchangersExpand
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Superpriming of synaptic vesicles after their recruitment to the readily releasable pool
Significance During sustained nerve activity, synapses must continuously recycle vesicles. We used the unique opportunities for quantitative analysis offered by the calyx of Held synapse to studyExpand
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Presynaptic Release Probability and Readily Releasable Pool Size Are Regulated by Two Independent Mechanisms during Posttetanic Potentiation at the Calyx of Held Synapse
At the immature calyx of Held, the fast decay phase of a Ca2+ transient induced by tetanic stimulation (TS) was followed by a period of elevated [Ca2+]i for tens of seconds, referred to asExpand
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Target Cell-Specific Involvement of Presynaptic Mitochondria in Post-Tetanic Potentiation at Hippocampal Mossy Fiber Synapses
Previous studies indicate that boutons from the same axon exhibit distinct Ca2+ dynamics depending on the postsynaptic targets. Mossy fibers of hippocampal granule cells innervate synaptic targetsExpand
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Mechanics of tidally driven fractures in Europa's ice shell
Abstract A fracture mechanics model is developed for the initiation and propagation of a crack through a porous ice layer of finite thickness under gravitational overburden. It is found that surfaceExpand
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Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.
Parkinson disease (PD) involves the selective loss of midbrain dopamine (mDA) neurons and is a possible target disease for stem cell-based therapy. Human induced pluripotent stem cells (hiPSCs) are aExpand
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Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
The prolonged effects of N-methyl-D-aspartate (NMDA) receptor activation on the proliferation and differentiation of hippocampal neural progenitor cells (NPCs) were studied. Under conditions ofExpand
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L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes.
  • Y. Song, H. Cho, +5 authors W. Ho
  • Medicine, Chemistry
  • Journal of molecular and cellular cardiology
  • 1 April 2010
The Ca(2+)-dependent facilitation (CDF) of L-type Ca(2+) channels, a major mechanism for force-frequency relationship of cardiac contraction, is mediated by Ca(2+)/CaM-dependent kinase II (CaMKII).Expand
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Functional Recapitulation of Smooth Muscle Cells Via Induced Pluripotent Stem Cells From Human Aortic Smooth Muscle Cells
Rationale: Generation of induced pluripotent stem (iPS) cells has been intensively studied by a variety of reprogramming methods, but the molecular and functional properties of the cellsExpand
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The-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor
A plastic privacy lock for recreation vehicles and the like includes an outside handle portion for the outside of a door and an inside portion for the inside of a door. The outside portion includesExpand
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