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Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives.
BACKGROUND Familial predisposition as a risk factor for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) carriers has not been thoroughly explored. METHODS The HCC risk associated with… Expand
Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma.
- M. Yu, S. W. Cheng, +9 authors C. Chen
- Medicine, Biology
- Journal of the National Cancer Institute
- 20 December 2000
BACKGROUND Worldwide, hepatocellular carcinoma (HCC) is more prevalent in men than in women, suggesting that sex hormones and/or X-chromosome-linked genes may be involved in hepatocarcinogenesis. We… Expand
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis
Hepatitis C virus (HCV) causes a persistent infection, chronic hepatitis and hepatocellular carcinoma. HCV NS5A, one of non-structural proteins of HCV, was suggested to play a role in oncogenic… Expand
Hepatitis B vaccination in patients with chronic hepatitis C.
The aim of the study was to evaluate the safety, immunogenicity, and possible therapeutic effect of hepatitis B vaccine in patients with chronic hepatitis C. The subjects studied included three… Expand
Seroprevalence of antibody to hepatitis E virus among Chinese subjects in Taiwan.
Recently, with an available serological hepatitis E virus diagnostic kit, the prevalence of IgG antibody to hepatitis E virus among Chinese subjects in Taiwan was evaluated by means of a solid-phase… Expand
HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines.
BACKGROUND/AIMS HCV NS5A appears to play an important role in HCV resistance to IFN-alpha but the molecular mechanism is not fully elucidated. Most studies regarding the involvement of signal… Expand
Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells.
Induced pluripotent stem cells (iPSCs) with four reprogramming factors (Oct-4/Sox2/Klf-4/c-Myc) have been shown to differentiate into hepatic lineages. However, it was unclear whether obviation of… Expand
Des-γ-Carboxy (Abnormal) Prothrombin as a Serum Marker of Primary Hepatocellular Carcinoma
Abstract We detected des-γ-carboxy prothrombin, an abnormal prothrombin, in the serum of 69 of 76 patients (91 per cent) with biopsy-confirmed hepatocellular carcinoma (the mean level of the abnormal… Expand
ROLE OF CAESAREAN SECTION IN PREVENTION OF MOTHER-INFANT TRANSMISSION OF HEPATITIS B VIRUS
447 infants, born to mothers positive for hepatitis B e antigen and hepatitis B surface antigen (HBsAg), received hepatitis B immunisation. A higher rate of hepatitis B virus (HBV) infection was… Expand
Changes of the neuropeptides content and gene expression in spinal cord and dorsal root ganglion after noxious colorectal distension
Visceral pain/hypersensitivity is a cardinal symptom of functional gastrointestinal disorders. With their peripheral and central (spinal) projections, sensory neurons in the dorsal root ganglia (DRG)… Expand