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Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae.
TLDR
The purified PikC cytochrome P450 monooxygenase catalyzes the in vitro hydroxylation of 7 and pikromycin to yield 9 and 10, respectively, thus expanding the substrate- and regio-flexibility of this enzyme.
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Enhanced production of hydroxylated macrolides from the pikromycin pathway of Streptomyces venezuelae
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Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae
TLDR
A successful attempt for a heterologous expression of Tyl PKS is demonstrated in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin PKS using two compatible low-copy plasmids, each under the control of a pikAI promoter.
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A sorbitol-selective fluorescence sensor
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The role of a second protein (Des VIII) in glycosylation for the biosynthesis of hybrid macrolide antibiotics in Streptomyces venezuelae
The function of the desVIII gene in the pikromycin producer Streptomyces venezuelae was characterized by gene deletion and complementation analysis. In addition to the DesVII glycosyltransferase, the…
Structural diversification of macrolactones by substrate-flexible cytochrome P450 monooxygenases
TLDR
This is the first report of C-4 hydroxylation activity of cytochrome P450 monooxygenase involved in the biosynthesis of 14-membered macrolides.
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Hydroxylation of Indole by PikC Cytochrome P450 from Streptomyces venezuelae and Engineering Its Catalytic Activity by Site-Directed Mutagenesis
TLDR
The results demonstrate the promising application of P450s originating from Streptomyces, normally involved in polyketide biosynthesis, to generate a diverse array of other industrially useful compounds.
The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis.
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Identification of a cytochrome P450 hydroxylase gene involved in rifamycin biosynthesis by Amycolatopsis mediterranei S699
TLDR
It is verified that the Orf0 protein, which is a P450 hydroxylase, is required for the production of rifamycin B in A. mediterranei.
Identification and Antibacterial Activity of a New Oleandomycin Derivative from Streptomyces antibioticus
  • B. Kim, H. Oh, J. Ahn
  • Chemistry, Biology
    The Journal of Antibiotics
  • 1 March 2005
TLDR
The new oleandomycin derivative has antibacterial activities similar to those of ole fandomycin agaisnt Enterococcus faecalis, Bacillus subtilis and Staphylococcus aureus.
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