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Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
- S. Lee, N. Lumelsky, L. Studer, J. M. Auerbach, R. McKay
- Medicine, Biology
- Nature Biotechnology
- 1 June 2000
Embryonic stem (ES) cells are clonal cell lines derived from the inner cell mass of the developing blastocyst that can proliferate extensively in vitro and are capable of adopting all the cell fates… Expand
Parvalbumin-Positive Basket Cells Differentiate among Hippocampal Pyramidal Cells
CA1 pyramidal cells (PCs) are not homogeneous but rather can be grouped by molecular, morphological, and functional properties. However, less is known about synaptic sources differentiating PCs.… Expand
The Influence of Thoracic Inlet Alignment on the Craniocervical Sagittal Balance in Asymptomatic Adults
- S. Lee, Ki-tack Kim, E. Seo, K. Suk, Yoon-Ho Kwack, Eun-Seok Son
- Journal of spinal disorders & techniques
- 1 April 2012
Study Design: A prospective radiographic study. Objectives: To analyze the relationship between craniocervical sagittal balance and thoracic inlet (TI) alignment and to present the parameters that… Expand
In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neurons.
Human embryonic stem (hES) cells, due to their capacity of multipotency and self-renewal, may serve as a valuable experimental tool for human developmental biology and may provide an unlimited cell… Expand
Regulation of Fast-Spiking Basket Cell Synapses by the Chloride Channel ClC–2
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor–mediated synaptic… Expand
Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.
Organoid techniques provide unique platforms to model brain development and neurological disorders. Whereas several methods for recapitulating corticogenesis have been described, a system modeling… Expand
Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo.
Lithium has been demonstrated to increase neurogenesis in the dentate gyrus of rodent hippocampus. The present study was undertaken to investigate the effects of lithium on the proliferation and… Expand
Distinct Endocannabinoid Control of GABA Release at Perisomatic and Dendritic Synapses in the Hippocampus
Endocannabinoid-mediated retrograde synaptic signaling is a key regulator of GABA release at synapses formed on the perisomatic region of pyramidal cells by basket cells that coexpress the… Expand
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.
- Yong-Hee Rhee, Ji-Yun Ko, +15 authors S. Lee
- Medicine, Biology
- The Journal of clinical investigation
- 1 June 2011
Parkinson disease (PD) involves the selective loss of midbrain dopamine (mDA) neurons and is a possible target disease for stem cell-based therapy. Human induced pluripotent stem cells (hiPSCs) are a… Expand
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
The prolonged effects of N-methyl-D-aspartate (NMDA) receptor activation on the proliferation and differentiation of hippocampal neural progenitor cells (NPCs) were studied. Under conditions of… Expand