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Autocrine VEGF Signaling Is Required for Vascular Homeostasis
Vascular endothelial growth factor (VEGF) is essential for developmental and pathological angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF is required for the… Expand
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
- T. Chen, A. Luque, S. Lee, S. M. Anderson, T. Segura, M. Iruela-Arispe
- Biology, Medicine
- The Journal of cell biology
- 22 February 2010
Matrix-bound VEGF elicits more distinct vascular effects than soluble VEGF, including prolonged VEGFR2 activation with altered patterns of tyrosine activation and downstream enhancement of the… Expand
Threshold for radiation-related severe mental retardation in prenatally exposed A-bomb survivors: a re-analysis.
Significant effects on the developing human brain of exposure to ionizing radiation are seen among individuals exposed in the 8th-25th week after ovulation. These effects, particularly in the highly… Expand
Preoperative gadoxetic acid-enhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma.
BACKGROUND & AIMS This study aimed to identify preoperative magnetic resonance (MR) imaging biomarkers for predicting microvascular invasion (MVI), to determine their diagnostic performance and to… Expand
High Density Polyethylene Composites Reinforced with Hybrid Inorganic Fillers: Morphology, Mechanical and Thermal Expansion Performance
- Runzhou Huang, X. Xu, S. Lee, Y. Zhang, Birm-June Kim, Qinglin Wu
- Materials Science, Medicine
- 1 September 2013
The effect of individual and combined talc and glass fibers (GFs) on mechanical and thermal expansion performance of the filled high density polyethylene (HDPE) composites was studied. Several… Expand
Analysis of mannose-binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population.
Mannose-binding lectin (MBL) is a C-type lectin produced by the liver and involved in the innate immune response. We have analyzed six SNPs of MBL2 gene--three at promoter (-550, -435, and -221), one… Expand
MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis.
Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during mammalian differentiation, the specific genomic sites targeted for H3NT proteolysis and the… Expand
Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy
- C. Domigan, C. M. Warren, +12 authors M. Iruela-Arispe
- Biology, Medicine
- Journal of Cell Science
- 15 June 2015
ABSTRACT Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and… Expand
Plant size, not age, regulates growth and gas exchange in grafted Scots pine trees.
We studied the effect of scion donor-tree age on the physiology and growth of 6- to 7-year-old grafted Scots pine (Pinus sylvestris L.) trees (4 and 5 years after grafting). Physiological… Expand
Growth factor gradients in vascular patterning.
- Andrea Lundkvist, S. Lee, L. Iruela-Arispe, C. Betsholtz, H. Gerhardt
- Chemistry, Medicine
- Novartis Foundation symposium
- 11 September 2007
Growth factor gradients regulate many developmental processes. VEGF-A is distributed in a graded fashion in growing tissues in order to direct sprouting of new vessels. Growth factor gradients can be… Expand