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The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview
The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems. Over the past few years a renewed interest in the LHb has emerged due toExpand
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Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice
The lateral habenula (LHb) encodes aversive signals, and its aberrant activity contributes to depression-like symptoms. However, a limited understanding of the cellular mechanisms underlying LHbExpand
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Synaptic and cellular profile of neurons in the lateral habenula
The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neuronsExpand
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Open Access
Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain
In humans, affective consequences of neuropathic pain, ranging from depression to anxiety and anhedonia, severely impair quality of life and are a major disease burden, often requiring specificExpand
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Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior
A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamusExpand
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PPARα Regulates Cholinergic-Driven Activity of Midbrain Dopamine Neurons via a Novel Mechanism Involving α7 Nicotinic Acetylcholine Receptors
Ventral tegmental area dopamine neurons control reward-driven learning, and their dysregulation can lead to psychiatric disorders. Tonic and phasic activity of these dopaminergic neurons depends onExpand
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Open Access
Maternal Immune Activation Disrupts Dopamine System in the Offspring
Background: In utero exposure to maternal viral infections is associated with a higher incidence of psychiatric disorders with a supposed neurodevelopmental origin, including schizophrenia. Hence,Expand
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Open Access
Regulates Cholinergic-Driven Activity of Midbrain Dopamine Neurons via a Novel Mechanism Involving 7 Nicotinic Acetylcholine Receptors
Miriam Melis,1,2 Simona Scheggi,3 Gianfranca Carta,1 Camilla Madeddu,1 Salvatore Lecca,1 Antonio Luchicchi,1 Francesca Cadeddu,1 Roberto Frau,1 Liana Fattore,2 Paola Fadda,1 M. Grazia Ennas,1 M.Expand
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Open Access
The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 andExpand
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Open Access
Sex-specific tonic 2-arachidonoylglycerol signaling at inhibitory inputs onto dopamine neurons of Lister Hooded rats
Addiction as a psychiatric disorder involves interaction of inherited predispositions and environmental factors. Similarly to humans, laboratory animals self-administer addictive drugs, whoseExpand
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Open Access