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Free DNA in the serum of cancer patients and the effect of therapy.
A radioimmunoassay for ng quantities of DNA was developed. [125l]lododeoxyuridine-labeled DNA was used as the antigen, and the serum of a lupus erythematosus patient served as the source of antibody.… Expand
Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease
Previous studies showed that patients with neoplasms of various types and origins have abnormally high concentration of DNA in their serum. The current work compares circulating DNA levels in… Expand
Free DNA in the serum of rheumatoid arthritis patients.
Seventy patients with classical or definite rheumatoid arthritis (RA) were studied in an attempt to correlate the serum levels of free DNA with other features. In 26 patients (37%), levels of DNA… Expand
Usefulness of tumor markers in serum and bronchoalveolar lavage of patients undergoing fiberoptic bronchoscopy.
- N. Goldstein, M. Lippmann, S. Goldberg, A. Fein, B. Shapiro, S. León
- The American review of respiratory disease
- 1 July 1985
To evaluate the diagnostic usefulness of simultaneous determinations of 4 tumor markers (carcinoembryonic antigen, calcitonin, creatinine kinase-BB, and DNA), we studied 31 patients with lung cancer,… Expand
DNA in synovial fluid and the circulation of patients with arthritis.
- S. León, M. Revach, G. Ehrlich, R. Adler, V. Petersen, B. Shapiro
- Arthritis and rheumatism
- 1 September 1981
DNA levels were measured in synovial fluids and sera of 106 patients with rheumatoid arthritis (RA), osteoarthritis (OA), gout, pseudogout, and posttraumatic arthritis (TRA). In synovial fluids, the… Expand
Avidity of antibodies in sle
The avidity of antibodies to DNA in the sera of 8 patients with SLE was determined by saturation analysis and Scatchard plots. Five of the patients had severe lupus nephritis; the other 3 had… Expand
Isolation and properties of mitochondrial RNA from yeast.
Abstract A purification procedure for the isolation of mitochondrial RNA from yeast is described. Three major components with S values of 23, 16, and 4S were found, as well as two minor components of… Expand
Radioimmunoassay for nanogram quantities of DNA.
- S. León, A. Green, M. Yaros, B. Shapiro
- Biology, Medicine
- Journal of immunological methods
- 1 December 1975
A direct competitive binding radioimmunoassay for DNA has been developed, using 125I-iododeoxyuridine-labelled DNA as the antigen and the serum from a patient with systemic lupus erythematosus. The… Expand
A comparison of DNA and DNA-binding protein levels in malignant disease.
Abstract Measurements of serum concentrations of DNA and the DNA-binding protein C3DP by radioimmunoassay showed that the levels of both substances tend to increase in cancer patients during active… Expand
In vitro protection against radiation damage to template activity in DNA synthesis.
- S. León, G. Kollmann, B. Shapiro
- Chemistry, Medicine
- International journal of radiation biology and…
SummaryIn vitro protection against radiation-induced functional changes in DNA was studied by measuring DNA template activity in enzymatic DNA synthesis. Exposures up to 28 kR inhibited the priming… Expand