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Adenosine in the central nervous system: release mechanisms and extracellular concentrations
Adenosine has several functions within the CNS that involve an inhibitory tone of neurotransmission and neuroprotective actions in pathological conditions. The understanding of adenosine productionExpand
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Brief, repeated, oxygen‐glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors
Ischemic preconditioning in the brain consists of reducing the sensitivity of neuronal tissue to further, more severe, ischemic insults. We recorded field epsps (fepsps) extracellularly fromExpand
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Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices
In the present study we investigated the role of A2A adenosine receptors in hippocampal synaptic transmission under in vitro ischaemia‐like conditions. The effects of adenosine, of the selective A2AExpand
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Interactions among adenosine deaminase, adenosine A1 receptors and dopamine D1 receptors in stably cotransfected fibroblast cells and neurons
The role of adenosine deaminase in the interactions between adenosine A(1) and dopamine D(1) receptors was studied in a mouse fibroblast cell line stably cotransfected with human D(1) receptor andExpand
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The source of brain adenosine outflow during ischemia and electrical stimulation
Adenosine outflow and adenosine and adenine nucleotide content of hippocampal slices were evaluated under two different experimental conditions: ischemia-like conditions and electrical stimulationExpand
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Investigations into the Adenosine Outflow from Hippocampal Slices Evoked by Ischemia‐Like Conditions
Abstract: The characteristics of adenosine and inosine outflow evoked by 5 min of ischemia‐like conditions in vitro (superfusion with glucose‐free Krebs solution gassed with 95% N2/5% CO2) wereExpand
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Adenosine Extracellular Brain Concentrations and Role of A2A Receptors in Ischemia
Abstract: Various experimental approaches have been used to determine the concentration of adenosine in extracellular brain fluid. The cortical cup technique or the microdialysis technique, whenExpand
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Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices
The application of an ischaemic insult in hippocampal slices results in the depression of synaptic transmission, mainly attributed to the activation of A1 adenosine receptors by adenosine released inExpand
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In vivo regulation of extracellular adenosine levels in the cerebral cortex by NMDA and muscarinic receptors.
The adenosine concentration in samples of perfusate was determined 24 h after implantation of microdialysis fibre in the cortex. High performance liquid chromatography coupled with a fluorometricExpand
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Temporal correlation between adenosine outflow and synaptic potential inhibition in rat hippocampal slices during ischemia-like conditions
The temporal correlation between adenosine outflow and changes in field excitatory post synaptic potentials (fEPSP) occurring during ischemia-like conditions was investigated in rat hippocampalExpand
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