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Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies.
TLDR
Although these results need to be further validated in larger cohorts, they indicate that the daily routine evaluation of the PD-L1 expression in diagnostic biopsies can be misleading in defining the sensitivity to treatment with PD- L1 targeted therapy.
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Sarcomatoid lung cancer (spindle/giant cells): an aggressive disease?
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Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility
TLDR
The frequency of TT-UMP is low in a single institution, diagnostic reproducibility is within the same range as other published data on follicular-patterned thyroid tumours, and the ancillary methods have a low impact on aiding diagnosis of such lesions.
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Candidate mechanisms for capecitabine-related hand-foot syndrome.
TLDR
TP-facilitated local production of 5FU in the palm during capecitabine treatment could explain the occurrence of Hand-foot syndrome, and this observation may support future strategies to limit the occurrences of HFS during cape citabine therapy.
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Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.
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MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib
TLDR
It is observed that miR-375 overexpression was associated with decreased cell proliferation and synergistically increased sensitivity to vandetanib, the clinically relevant treatment of metastatic MTC, and this approach identified SEC23A as a bona fide miR -375 target, which was validated by immunoblotting and immunohistochemistry of non-tumor and pathological thyroid tissue.
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Chemoradiation in anaplastic thyroid carcinomas.
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Management of Invasive Squamous Cell Carcinomas of the Conjunctiva.
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Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer—Just About Ready for Prime-Time?
TLDR
Views are provided on the current technological status and evidence for clinical applications of multiplexing and how it could be applied to optimize clinical management of patients with lung cancer.
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Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia.
TLDR
Investigation in an in vitro model of PMNL transepithelial migration and in the intestinal mucosa of patients with CD the expression and regulation of ADAM17 and TIMP3 in intestinal epithelial cells (IEC) showed early posttranscriptional upregulation of ADam17 in IEC linked to PMNLtransepitocyte migration and a high activity of CD.
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