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Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
TLDR
It is concluded that liver PKC is increased in NIDDM, a change that is not secondary to hyperglycemia, and it is possible that PKC-mediated phosphorylation of some component in the insulin signaling cascade contributes to the insulin resistance observed in N IDDM.
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Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4.
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Sequential changes in the activities of lipoprotein lipase and lipogenic enzymes during tumor growth in rats.
TLDR
A defect in clearance, due to the decrease in the activity of adipose tissue LPL, may be responsible for the early development of hypertriglyceridemia during tumor growth.
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PPARgamma activation induces autophagy in breast cancer cells.
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Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats.
TLDR
It is indicated that estradiol increases the availability of lipid substrate to exercising muscle from multiple sources, including adipose, plasma, and intracellular muscle triacylglycerol.
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The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.
TLDR
The protection offered by celecoxib was associated with significantly lower concentrations of prostacyclin and prostaglandin E(2) in mammary tumors and their adjacent mammary glands.
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Nutritional emphysema in the rat. Influence of protein depletion and impaired lung growth.
TLDR
Collagen and elastin content were reduced in emphysematous lungs; however, the levels were not below those found prior to nutritional intervention, suggesting that lack of growth, not depletion, accounts for the reduced content.
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Cyclooxygenase (COX)-2-dependent effects of the inhibitor SC236 when combined with ionizing radiation in mammary tumor cells derived from HER-2/neu mice.
TLDR
It is indicated that the COX-2 inhibitor SC236 reduced cell growth and arrested cells in the G2-M phase of the cell cycle by mechanisms that are both dependent and independent of PG production while its effects on VEGF appear to be independent of COx-2.
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Effect of total parenteral nutrition, systemic sepsis, and glutamine on gut mucosa in rats.
The effect of the combination of total parenteral nutrition (TPN) and systemic sepsis on mucosal morphology and protein synthesis was investigated. Rats were given a standard TPN mixture consisting…
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3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.
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