• Publications
  • Influence
Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus
Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of avian influenza A viruses to mammals.Expand
  • 268
  • 15
  • Open Access
Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression
Human papillomaviruses (HPVs) are DNA viruses associated with major human cancers. As such there is a strong interest in developing new means, such as vaccines and microbicides, to prevent HPVExpand
  • 251
  • 11
Major Histocompatibility Complex Class I Haplotype Diversity in Chinese Rhesus Macaques
The use of Chinese-origin rhesus macaques (Macaca mulatta) for infectious disease immunity research is increasing despite the relative lack of major histocompatibility complex (MHC) class IExpand
  • 41
  • 5
  • Open Access
Major histocompatibility complex genotyping with massively parallel pyrosequencing
Major histocompatibility complex (MHC) genetics dictate adaptive cellular immune responses, making robust MHC genotyping methods essential for studies of infectious disease, vaccine development andExpand
  • 137
  • 4
  • Open Access
Whole-Genome Characterization of Human and Simian Immunodeficiency Virus Intrahost Diversity by Ultradeep Pyrosequencing
ABSTRACT Rapid evolution and high intrahost sequence diversity are hallmarks of human and simian immunodeficiency virus (HIV/SIV) infection. Minor viral variants have important implications for drugExpand
  • 68
  • 4
  • Open Access
Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques
In recent years, the use of cynomolgus macaques in biomedical research has increased greatly. However, with the exception of the Mauritian population, knowledge of the MHC class II genetics of theExpand
  • 21
  • 4
Ultradeep Pyrosequencing Detects Complex Patterns of CD8+ T-Lymphocyte Escape in Simian Immunodeficiency Virus-Infected Macaques
ABSTRACT Human and simian immunodeficiency viruses (HIV/SIV) exhibit enormous sequence heterogeneity within each infected host. Here, we use ultradeep pyrosequencing to create a comprehensive pictureExpand
  • 78
  • 3
  • Open Access
MHC Heterozygote Advantage in Simian Immunodeficiency Virus–Infected Mauritian Cynomolgus Macaques
This manuscript demonstrates unambiguous major histocompatibility complex heterozygote advantage in macaque monkeys infected with the same strain of simian immunodeficiency virus, suggesting that aExpand
  • 71
  • 2
Novel antivirals inhibit early steps in HPV infection.
The future incidence of cervical cancer is forecast to decline because of the remarkably effective prophylactic vaccines against human papillomaviruses. However, lack of access to these expensiveExpand
  • 7
  • 2
A novel single cDNA amplicon pyrosequencing method for high-throughput, cost-effective sequence-based HLA class I genotyping.
Human leukocyte antigen (HLA) genotype influences the immune response to pathogens and transplanted tissues; accurate HLA genotyping is critical for clinical and research applications. Sequence-basedExpand
  • 50
  • 1