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Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience.
If it is accepted from the P-1 findings that women at increased risk for invasive cancer are candidates for an intervention such as TAM, then it would seem that women with a history of DCIS should also be considered for such therapy in addition to radiation therapy. Expand
Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.
Although I-IBTR increased the risk for breast cancer-related death, radiation therapy and tamoxifen reduced I- IBTR, and long-term prognosis remained excellent after breast-conserving surgery for DCIS. Expand
Morbidity results from the NSABP B‐32 trial comparing sentinel lymph node dissection versus axillary dissection
Three year post‐surgical morbidity levels were compared between patients with negative sentinel lymph node dissection alone (SLND) and those with negative sentinel node dissection and negativeExpand
Association between media use in adolescence and depression in young adulthood: a longitudinal study.
Television exposure and total media exposure in adolescence are associated with increased odds of depressive symptoms in young adulthood, especially in young men. Expand
Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial.
Original exemestane assignment resulted in non-statistically significant improvement in DFS and in statisticallysignificant improvement in RFS, and toxicity, assessed up to time of unblinding, was acceptable for the adjuvant setting. Expand
Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth
This study identifies IRS-1 as a key regulator of PI3K within malignant cells within lung adenocarcinomas and describes the first description of a secreted proteinase gaining access to the inside of a cell and altering intracellular signaling. Expand
Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer.
Overall survival was improved in patients with amenorrhea for 6 months or more across all treatment groups, independently of estrogen-receptor status, and Sequential ACT improved disease-free survival as compared with doxorubicin-docetaxel or concurrent ACT, and it improved overall survival. Expand
Neurotoxicity from oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: NSABP C-07.
Oxaliplatin causes significant neurotoxicity, experienced primarily in the hands during therapy and in the feet during follow-up, and in a minority of patients the neurotoxicity is long lasting. Expand
(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.
The results suggest that (-)-gossypol is a potent and novel therapeutic able to overcome apoptosis resistance by specifically targeting the activity of antiapoptotic Bcl-2 family members. Expand
Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.
Non-small cell lung cancer cells respond to estrogens/antiestrogens by altering endogenous gene expression and support a model in which ICI 182,780 reduces proliferation of NSCLC cells via its ability to disrupt ER signaling. Expand