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A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines
TLDR
These data demonstrate shared mechanisms of action of AZA and DAC on DNA-mediated markers of activity, but distinctly different effects in their actions on cell viability, protein synthesis, cell cycle, and gene expression. Expand
In vivo Target Modulation and Biological Activity of CHIR-258, a Multitargeted Growth Factor Receptor Kinase Inhibitor, in Colon Cancer Models
TLDR
Evidence is provided that biological activity of CHIR-258 in tumors correlates with efficacy and aids in the identification of potential biomarkers of this multitargeted receptor tyrosine kinase inhibitor. Expand
Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.
TLDR
Rec recombinant human KGF used as a pretreatment in several mouse models of chemotherapy and/or radiation-induced gastrointestinal injury significantly improved mouse survival and indicates that KGF may be therapeutically useful to lessen the intestinal side effects of current cancer therapy regimens. Expand
Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.
TLDR
Results demonstrate rKGF can induce epithelial cell activation throughout the GI tract and liver and suggest endogenous KGF may be a normal paracrine mediator of growth within the gut. Expand
CHIR-258: A Potent Inhibitor of FLT3 Kinase in Experimental Tumor Xenograft Models of Human Acute Myelogenous Leukemia
TLDR
The data indicate that CHIR-258 may be an effective therapy in FLT3-associated AML and warrants clinical trials. Expand
Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats.
TLDR
Administration of KGF after but not before induction of colitis significantly ameliorated tissue damage and macroscopic necrosis and microscopic ulcerations were reduced by 40%-50% at KGF doses of 1 and 5 mg/kg. Expand
The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells.
TLDR
In primary B-CLL tumor cells, the novel antagonist anti-CD40 monoclonal antibody, HCD122, inhibits CD40L-induced activation of signaling pathways, proliferation and survival, and secretion of cytokines, and is also a potent mediator of antibody-dependent cellular cytotoxicity (ADCC). Expand
Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines
TLDR
Evidence that FGF signaling pathways are active in a majority of human tumor cell lines is provided, and lends support to the development of anti‐tumor strategies that target FGFRs. Expand
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
TLDR
Observations indicate a close link between beta-catenin signaling and the regulation of VEGF-A expression in colon cancer. Expand
Antifungal activity of recombinant human macrophage colony-stimulating factor in models of acute and chronic candidiasis in the rat.
TLDR
It is shown that rhM-CSF treatment improved the therapeutic outcome in both the acute and chronic rat model of candidiasis when used with fluconazole, a standard fungistatic agent. Expand
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