• Publications
  • Influence
Genome sequence of the human malaria parasite Plasmodium falciparum
The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genomeExpand
  • 3,844
  • 168
  • PDF
Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria
The variant surface antigens expressed on Plasmodium falciparum–infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of varExpand
  • 178
  • 23
  • PDF
Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum.
Many pathogens evade the host immune response or adapt to their environment by expressing surface proteins that undergo rapid switching. In the case of Plasmodium falciparum, products of a multigeneExpand
  • 323
  • 22
  • PDF
Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates
BackgroundVar genes encode a family of virulence factors known as PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) which are responsible for both antigenic variation and cytoadherence ofExpand
  • 181
  • 22
  • PDF
Genome variation and evolution of the malaria parasite Plasmodium falciparum
Infections with the malaria parasite Plasmodium falciparum result in more than 1 million deaths each year worldwide. Deciphering the evolutionary history and genetic variation of P. falciparum isExpand
  • 192
  • 17
  • PDF
Antigenic variation at the infected red cell surface in malaria.
Many pathogens that either rely on an insect vector to complete their life cycle (e.g., Trypanosoma spp. and Borrelia spp.) or exist in a unique ecological niche where transmission from host to hostExpand
  • 381
  • 14
A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya.
The malarial parasite Plasmodium falciparum has acted as a potent selective force on the human genome. The particular virulence of this organism is thought to be due to the adherence of parasitisedExpand
  • 214
  • 13
  • PDF
A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum.
  • 267
  • 9
Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain.
The A4VAR is a variant antigen expressed by a clonal line that binds CD36 and intercellular adhesion molecule-1, ICAM-1. We have cloned and sequenced the extracellular domain coded by the A4var gene.Expand
  • 128
  • 9
Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue.
BACKGROUND Macrophage-migration inhibitory factor (MIF), one of the first cytokines described, has a broad range of proinflammatory properties. The genome sequencing project of Plasmodium falciparumExpand
  • 56
  • 9