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Isolation and identification of 6-desmethylnaproxen sulfate as a new metabolite of naproxen in human plasma.
- C. Kiang, C. Lee, S. Kushinsky
- Biology, ChemistryDrug metabolism and disposition: the biological…
Plasma profiles of 6-DMNS for normal and uremic subjects, obtained by a procedure involving differential enzymatic hydrolysis using arylsulfatase from H. pomatia, revealed that 6- DMNS was present from all subjects but in relatively high concentrations only in subjects with impaired renal function and that the extent of the conjugation is related directly to the severity of the dysfunction.
Creepage of estrogens vs. loss by sorption on glassware.
This work has found no evidence for sorption of estrogens onto glass from buffered aqueous solutions or decomposition in tightly closed containers in the absence of proteins.
A high-performance liquid chromatographic method for the simultaneous determination of nicardipine and its pyridine metabolite II in plasma.
The HPLC procedure is suitable for use in pharmacokinetic studies following administration of nicardipine hydrochloride to humans and has been validated by comparison with a GC-electron-capture detection procedure and with an HPLC/GC-ECD procedure, which gives the concentration of its pyridine metabolite II.
The isolation of 19-hydroxy-11-deoxycorticosterone and an unknown, active mineralocorticoid from bovine adrenal perfusions of progesterone.
Conjugated estrogens IV. Separation of urinary estrogens by gel-filtration and the effect of endogenous inhibitor on the rate and extent of hydrolysis by β-glucuronidase
Separation of conjugated urinary estrogens on columns of sephadex. II. Sequential separations.
Separation of conjugated urinary estrogens on columns of sephadex. I. Optimization of conditions.
Use of a "self-cleaning" oven to clean liquid scintillation vials and other glassware.
Separation of Mixtures of Œstrogens in Urinary Extracts using Gradient Elution Chromatography
The method consists of gradient elution chromatography on silica gel with progressively increasing concentration of ethyl acetate in benzene and the separation of a synthetic mixture of œstrogens is complete, and excellent recoveries are obtained.
Nasal absorption of nafarelin acetate, the decapeptide [D-Nal(2)6)]LHRH, in rhesus monkeys. I.
Nafarelin acetate, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys and the nasal dose response was highly nonlinear.