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Chemical ecology of endophytic fungi: origins of secondary metabolites.
Endophytes constitute a remarkably multifarious group of microorganisms ubiquitous in plants and maintain an imperceptible association with their hosts for at least a part of their life cycle. TheirExpand
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An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues.
The pentacyclic quinoline alkaloid camptothecin (1) is a potent antineoplastic agent. Two of its analogues, 9-methoxycamptothecin (2) and 10-hydroxycamptothecin (3), exhibit similar potency but doExpand
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Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro‐drug deoxypodophyllotoxin
Aims:  Isolation, identification and characterization of an endophytic fungus from Juniperus communis L. Horstmann, as a novel producer of deoxypodophyllotoxin and its in vitro antimicrobial assay.
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An endophytic fungus from Azadirachta indica A. Juss. that produces azadirachtin
Azadirachtin A and its structural analogues are a well-known class of natural insecticides having antifeedant and insect growth-regulating properties. These compounds are exclusive to the neem tree,Expand
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An endophytic fungus from Hypericum perforatum that produces hypericin.
For the first time, an endophytic fungus has been isolated from the stems of the medicinal herb Hypericum perforatum (St. John's Wort). The fungus produced the napthodianthrone derivative hypericin (Expand
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Endophytic fungi harbored in Cannabis sativa L.: diversity and potential as biocontrol agents against host plant-specific phytopathogens
The objective of the present work was isolation, phylogenetic characterization, and assessment of biocontrol potential of endophytic fungi harbored in various tissues (leaves, twigs, and apical andExpand
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Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites.
The biosynthetic potential of endophytic fungi has gained impetus in recent times owing to the continual discovery of fungal endophytes capable of synthesizing plant compounds. However, the sustainedExpand
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Metabolomics of Endophytic Fungi Producing Associated Plant Secondary Metabolites: Progress, Challenges and Opportunities
Microorganisms are indispensable for every aspect of human life, in fact all life on earth, although they cannot be seen by the naked eye. Since time immemorial, every process in the biosphere hasExpand
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Rethinking production of Taxol® (paclitaxel) using endophyte biotechnology.
Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery ofExpand
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Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis.
Fungal endophytes inhabit healthy tissues of all terrestrial plant taxa studied and occasionally produce host-specific compounds. We recently isolated an endophytic fungus, Fusarium solani, fromExpand
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