S. Kuruganti

Publications6
h-index4
Citations92
Highly Influential Citations5
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Functional analysis of the cis‐acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine
Many Drosophila cytochrome P450 or Cyp genes are induced by caffeine and phenobarbital (PB). To understand the induction mechanism, we created Drosophila S2 cell lines stably transformed with… Expand
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High expression of Cyp6g1, a cytochrome P450 gene, does not necessarily confer DDT resistance in Drosophila melanogaster.
Cytochrome P450 monooxygenases, a family of detoxifying enzymes, are thought to confer resistance to various insecticides including DDT. Daborn et al. [Daborn, P., Yen, J.L., Bogwitz, M., Le Goff,… Expand
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The Drosophila gypsy Insulator Supports Transvection in the Presence of the vestigial Enhancer
Though operationally defined as cis-regulatory elements, enhancers can also communicate with promoters on a separate homolog in trans, a mechanism that has been suggested to account for the ability… Expand
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Changes in chromatin structure correlate with transcriptional activity of nucleolar rDNA in polytene chromosomes
Ribosomal DNA genes (rDNA) are found in tandem arrays of hundreds of repeated genes, but only a fraction of these genes are actively transcribed. The regulatory mechanism controlling the transition… Expand
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A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family
The 12 distinct subtypes that comprise the interferon alpha (IFNα) family of cytokines possess anti-viral, anti-proliferative and immunomodulatory activities. They are implicated in the etiology and… Expand
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Studies on Cytochrome P450 genes in Drosophila melanogaster : Relationship between over expression and DDT resistance, and xenobiotic induction
Cytochrome P450 monooxygenases (CYPs), are involved in the metabolism of a diverse group of endogenous and xenobiotic compounds. In insects, CYPs are involved in conferring resistance against… Expand
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