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Diverging Alternative Splicing Fingerprints in the Transforming Growth Factor-β Signaling Pathway Identified in Thoracic Aortic Aneurysms
- S. Kurtovic, V. Paloschi, L. Folkersen, J. Gottfries, A. Franco‐Cereceda, P. Eriksson
- BiologyMolecular Medicine
The results suggest that dilatation in TAV and BAV patients has different alternative splicing fingerprints in the TGFβ pathway, andAlternative splicing is a common feature of TAA formation.
Unraveling Divergent Gene Expression Profiles in Bicuspid and Tricuspid Aortic Valve Patients with Thoracic Aortic Dilatation: The ASAP Study
The divergent gene expression profiles indicate that there are fundamental differences in TAA etiology in BAV and TAV patients, and Immune response activation solely in the aortic media of T AV patients suggests that inflammation is involved in T AA formation in TAV but not in B AV patients.
Impaired Splicing of Fibronectin Is Associated With Thoracic Aortic Aneurysm Formation in Patients With Bicuspid Aortic Valve
- V. Paloschi, S. Kurtovic, P. Eriksson
- Medicine, BiologyArteriosclerosis, Thrombosis and Vascular Biology
- 1 March 2011
Gene set enrichment analysis together with multivariate and univariate data analyses of mRNA expression suggested that differences in the transforming growth factor-&bgr; signaling pathway may explain the impaired EDA inclusion in BAV patients.
Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.
Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase.
The psychological disturbances of war-traumatized adolescents in rural and urban areas of Bosnia and Herzegovina and correlation with poverty and hopelessness
Life in poor material conditions worsened psychological war consequences and academic achievement and academic achievements were negatively associated with age, severity of PTSD, depression, suicidal thoughts, hopelessness and with the mean number of trauma experiences.
A Minimum Data Set for Sharing Biobank Samples, Information, and Data: MIABIS.
An updated version of the minimum data set for biobanks and studies using human biospecimens, called MIABIS (Minimum Information About BIobank data Sharing), which consists of 52 attributes describing a biobank's content to facilitate data discovery through harmonization of data elements describing aBiobank at the aggregate level.
Identification of emerging quasi-species in directed enzyme evolution.
It is demonstrated using a library of glutathione transferases that the functional properties are not uniformly distributed in substrate-activity space but form clusters, or quasi-species, which can be regarded as the proper developing units in molecular evolution.