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Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer
The Hedgehog (Hh) signaling pathway functions as an organizer in embryonic development. Genetic analysis has demonstrated a critical role for the Hh pathway in mammary gland morphogenesis. Disruption… Expand
Purification, characterization and biological significance of tumor-derived exosomes.
- Kenichiro Koga, K. Matsumoto, +8 authors M. Katano
- Biology, Medicine
- Anticancer research
- 1 November 2005
Exosomes are nanovesicles that are released into the extracellular environment during the fusion of multivesicular bodies with the plasma membrane. Exosomes released from dendritic cells, dexosomes,… Expand
The Internal Biliary Fistula – Reappraisal of Incidence, Type, Diagnosis and Management of 33 Consecutive Cases
- H. Yamashita, K. Chijiiwa, Y. Ogawa, S. Kuroki, M. Tanaka
- HPB surgery : a world journal of hepatic…
To reevaluate the current features of spontaneous internal biliary fistulas, we reviewed 1,929 consecutive patients who had been treated for biliary tract diseases during the recent 12-year period.… Expand
The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells.
The side population (SP) and the CD44(+)/CD24(-/low) population have been reported in separate studies to include more tumorigenic cells than other populations, and to have the ability to form new… Expand
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
Constitutive activation of signal transducer and activator of transcription (Stat) proteins has been demonstrated in a wide variety of malignancies. In this study, we elucidated the significance of… Expand
Role of leukotrienes on hepatic ischemia/reperfusion injury in rats.
- Yuji Takamatsu, K. Shimada, K. Chijiiwa, S. Kuroki, K. Yamaguchi, M. Tanaka
- The Journal of surgical research
- 1 June 2004
BACKGROUND Leukotrienes (LT), composed of cysteinyl LT (cLT; LTC(4), LTD(4), and LTE(4)) and LTB(4), are potent lipid mediators enhancing the vascular permeability and recruitment of neutrophils,… Expand
The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.
Understanding the expression patterns of estrogen receptor-alpha (ERalpha) is essential for determining therapeutic strategies for patients with breast cancer. The prognosis of patients with… Expand
Relation of Biliary Bile Acid Output to Hepatic Adenosine Triphosphate Level and Biliary Indocyanine Green Excretion in Humans
We have previously demonstrated that there are two subgroups of patients with different types of biliary bile acid output after relief of obstructive jaundice by percutaneous transhepatic biliary… Expand
Novel link between estrogen receptor alpha and hedgehog pathway in breast cancer.
Ligand-dependent constitutive activation of the hedgehog (Hh) pathway is important in the development of various carcinomas including breast cancer. A link between estrogen receptor alpha (ERalpha)… Expand
Current management and long-term prognosis of hepatolithiasis.
- K. Chijiiwa, H. Yamashita, J. Yoshida, S. Kuroki, M. Tanaka
- Archives of surgery
- 1 February 1995
OBJECTIVE To assess the surgical and endoscopic treatment results and long-term prognosis of hepatolithiasis. DESIGN Retrospective case series. SETTING University hospital. PATIENTS Eighty-five… Expand