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Therapeutic Potential of Mesenchymal Stem Cells Producing Interferon‐α in a Mouse Melanoma Lung Metastasis Model
- C. Ren, S. Kumar, D. Chanda, J. Chen, J. Mountz, S. Ponnazhagan
- Biology, Medicine
- Stem cells
- 1 September 2008
Adult stem cells represent a potential source for cell‐based therapy of cancer. The present study evaluated the potential of bone marrow‐derived mesenchymal stem cells (MSC), genetically modified to… Expand
Placement of Half-Pins for Supra-acetabular External Fixation: An Anatomic Study
An alternative location for placement of half-pins during pelvic external fixation is the dense supra-acetabular bone in the region of the anterior-inferior iliac spine. Although these fixators have… Expand
Periprosthetic humeral fractures after shoulder arthroplasty.
- S. Kumar, J. Sperling, George Haidukewych, R. Cofield
- The Journal of bone and joint surgery. American…
BACKGROUND Currently, there is little information concerning periprosthetic humeral fractures after shoulder arthroplasty. Therefore, we reviewed our experience with these fractures to determine the… Expand
Does nonneutral evolution shape observed patterns of DNA variation in animal mitochondrial genomes?
Early studies of animal mitochondrial DNA (mtDNA) assumed that nucleotide sequence variation was neutral. Recent analyses of sequences from a variety of taxa have brought the validity of this… Expand
Dynamics of Mechanosensitive Neural Stem Cell Differentiation
Dynamics of Mechanosensitive Neural Stem Cell Differentiation Sebastian Rammensee, Michael S. Kang, Katerina Georgiou, Sanjay Kumar, and David V. Schaffer The authors acknowledge a necessary addition… Expand
How wide is the Genetic Base of Pulse Crops
Genetic base as revealed by the pedigree records of released varieties appears to be narrow in major pulse crops because of the frequent use of the same parents and their derivatives in breeding… Expand
SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity.
- J. Wilkinson-Berka, D. Jones, +6 authors R. Gilbert
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 April 2006
PURPOSE To determine whether SB-267268, a nonpeptidic antagonist of the alpha(v)beta3 and alpha(v)beta5 integrins, attenuates angiogenesis in a murine model of retinopathy of prematurity (ROP) and… Expand
Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion
Glioblastoma (GBM) tumors are thought to arise from a subpopulation of brain tumor-initiating cells (BTICs), which mediate therapeutic resistance and seed new tumors. Virtually nothing is known about… Expand
Bone homing of mesenchymal stem cells by ectopic α4 integrin expression
The pluripotent nature of mesenchymal stem cells (MSC) widens their potential for tissue regeneration and as vehicles for cell therapy in molecular medicine. Although the MSC are relatively easier to… Expand
Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect.
- S. Kumar, Chao Wan, G. Ramaswamy, T. Clemens, S. Ponnazhagan
- Molecular therapy : the journal of the American…
- 1 May 2010
The potential of mesenchymal stem cells (MSC) in tissue regeneration is increasingly gaining attention. There is now accumulating evidence that MSC make an important contribution to postnatal… Expand